Postmenopausal hormone therapy and mortality before and after the Women's Health Initiative study.
Postmenopausal hormone therapy and mortality before and after the Women's Health Initiative study.
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DOI：
10.1038/s41598-023-27731-z
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发表时间：
2023-01-11
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
权衡绝经后激素治疗（HT）的风险和益处已被证明是一种平衡行为。我们的目的是调查2002年妇女健康倡议（WHI）研究发表前后HT与死亡率之间的关系。该出版物发现，使用HT的风险超过受益，因此导致全身HT使用者患病率显著降低。2002年WHI的出版物也可能导致随后HT用户配置文件的变化，因为HT不再被推荐用于预防慢性病。这项队列研究包括两个人群，从1995年开始：从丹麦一般人群中随机抽取5%的单身女性样本（n = 52，388）和丹麦女性双胞胎样本（n = 15，261）。HT的使用在1995年、2000年、2005年和2010年进行了评估。HT，教育和死亡率之间的关联进行了调查，并控制潜在的未观察到的家族性混杂在一对内分析。在2000年，56-75岁的使用全身HT的单身患者的死亡率低于非使用者（风险比（HR）0.83，95%置信区间（CI）0.78-0.89）。2005年，该年龄组的死亡率与背景人群相似（HR 1.02，95% CI 0.94-1.11）。最近绝经后的双胞胎表现出类似的趋势。到2005年，全身HT使用者转为局部HT，其死亡率明显低于非使用者（HR范围为0.42至0.67，取决于年龄组）。总之，我们发现全身性HT使用的流行率在2002年后下降，全身性HT使用者的死亡率从2002年前的较低变为2002年后与背景人群相似。这表明最健康的用户决定放弃全身HT或改用局部HT，因为WHI出版后建议发生了变化。
Weighing risks and benefits of postmenopausal hormone therapy (HT) has proven a balancing act. We aimed to investigate the association between HT and mortality before and after the 2002 publication from the Women’s Health Initiative (WHI) study. This publication found that the risk of using HT outweighted the benefits, and thus it caused a marked reduction in systemic HT user prevalence. The 2002 WHI publication may also have caused a change in the subsequent HT user profile, as HT is no longer recommended in the prevention of chronic diseases. This cohort study included two populations followed from 1995: A 5% random sample of female singletons from the Danish general population (n = 52,388) and a sample of Danish female twins (n = 15,261). HT use was evaluated in 1995, 2000, 2005, and 2010. The association between HT, education, and mortality was investigated and controlled for potential unobserved familial confounding in a within-pair analysis. Singletons aged 56–75 using systemic HT in 2000 had a lower mortality compared to non-users (hazard ratio (HR) 0.83, 95% confidence interval (CI) 0.78–0.89). In 2005, the mortality was like that of the background population for this age group (HR 1.02, 95% CI 0.94–1.11). Recently postmenopausal twins showed a similar tendency. Systemic HT users, who had switched to local HT by 2005, had a substantially lower mortality than non-users (HR ranging from 0.42 to 0.67 depending on age group). In conclusion, we found that the prevalence of systemic HT use declined after 2002, and systemic HT users’ mortality changed from lower before 2002 to similar to that of the background population after 2002. This indicates that the healthiest users decided to either drop systemic HT or switcted to local HT, as recommendations changed following the WHI publication.
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影响因子：
120.7
作者：
Manson, JoAnn E.;Chlebowski, Rowan T.;Stefanick, Marcia L.;Aragaki, Aaron K.;Rossouw, Jacques E.;Prentice, Ross L.;Anderson, Garnet;Howard, Barbara V.;Thomson, Cynthia A.;LaCroix, Andrea Z.;Wactawski-Wende, Jean;Jackson, Rebecca D.;Limacher, Marian;Margolis, Karen L.;Wassertheil-Smoller, Sylvia;Beresford, Shirley A.;Cauley, Jane A.;Eaton, Charles B.;Gass, Margery;Hsia, Judith;Johnson, Karen C.;Kooperberg, Charles;Kuller, Lewis H.;Lewis, Cora E.;Liu, Simin;Martin, Lisa W.;Ockene, Judith K.;O'Sullivan, Mary Jo;Powell, Lynda H.;Simon, Michael S.;Van Horn, Linda;Vitolins, Mara Z.;Wallace, Robert B.
通讯作者：
Wallace, Robert B.
DOI：
10.1177/1745691610383511
发表时间：
2010-09
期刊：
Perspectives on psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
McGue M;Osler M;Christensen K
通讯作者：
Christensen K
影响因子：
2.6
作者：
Heinig, Miriam;Braitmaier, Malte;Haug, Ulrike
通讯作者：
Haug, Ulrike
影响因子：
7.7
作者：
McGue, Matt;Skytthe, Axel;Christensen, Kaare
通讯作者：
Christensen, Kaare
影响因子：
9.3
作者：
Meyer, Anna C.;Drefahl, Sven;Modig, Karin
通讯作者：
Modig, Karin