Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis.
Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis.
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DOI：
10.1016/j.isci.2021.103269
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发表时间：
2021-11-19
期刊：
影响因子：
5.8
通讯作者：
Majesky MW
中科院分区：
文献类型：
--
作者：
Okamura DM;Brewer CM;Wakenight P;Bahrami N;Bernardi K;Tran A;Olson J;Shi X;Yeh SY;Piliponsky A;Collins SJ;Nguyen ED;Timms AE;MacDonald JW;Bammler TK;Nelson BR;Millen KJ;Beier DR;Majesky MW
纤维化导致的实体器官衰竭是全球健康的巨大负担。刺鼠（Acomys）是陆生哺乳动物，可以再生严重的皮肤伤口，没有疤痕，以避免捕食。刺鼠是否也会再生内脏损伤尚不清楚。在这里，我们表明，尽管等效的急性梗阻性或缺血性肾损伤，多刺小鼠完全再生肾单位结构和器官功能，而没有纤维化，而C57 B1/6或CD 1小鼠进展到完全器官衰竭与广泛的肾纤维化。已经提出了两种脊椎动物再生机制，强调外在（促再生巨噬细胞）或内在（器官本身的存活细胞）控制。比较转录组分析显示，Acomys基因组在损伤时似乎准备通过存活的肾细胞启动再生，而巨噬细胞积聚直到约第7天才被检测到。因此，我们提供的证据，快速激活的基因表达签名再生伤口愈合的多刺小鼠肾脏。Acomys完全再生肾脏结构和功能，损伤后无纤维化存活细胞中快速激活的独特基因簇与再生对齐Acomys基因组似乎在肾损伤时保持平衡，启动再生动物生理学;分子生物学;发育生物学
Fibrosis-driven solid organ failure is an enormous burden on global health. Spiny mice (Acomys) are terrestrial mammals that can regenerate severe skin wounds without scars to avoid predation. Whether spiny mice also regenerate internal organ injuries is unknown. Here, we show that despite equivalent acute obstructive or ischemic kidney injury, spiny mice fully regenerate nephron structure and organ function without fibrosis, whereas C57Bl/6 or CD1 mice progress to complete organ failure with extensive renal fibrosis. Two mechanisms for vertebrate regeneration have been proposed that emphasize either extrinsic (pro-regenerative macrophages) or intrinsic (surviving cells of the organ itself) controls. Comparative transcriptome analysis revealed that the Acomys genome appears poised at the time of injury to initiate regeneration by surviving kidney cells, whereas macrophage accumulation was not detected until about day 7. Thus, we provide evidence for rapid activation of a gene expression signature for regenerative wound healing in the spiny mouse kidney. Acomys fully regenerate kidney structure and function without fibrosis after injury Unique gene clusters rapidly activated in surviving cells align with regeneration Acomys genome appears poised at the time of kidney injury to initiate regeneration Animal physiology; Molecular biology; Developmental biology
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DOI：
10.1146/annurev-pathol-020712-163930
发表时间：
2013-01-24
期刊：
Annual review of pathology
影响因子：
--
作者：
Duffield JS;Lupher M;Thannickal VJ;Wynn TA
通讯作者：
Wynn TA
影响因子：
41.5
作者：
Ferenbach, David A.;Bonventre, Joseph V.
通讯作者：
Bonventre, Joseph V.
影响因子：
64.8
作者：
Kuppe C;Ibrahim MM;Kranz J;Zhang X;Ziegler S;Perales-Patón J;Jansen J;Reimer KC;Smith JR;Dobie R;Wilson-Kanamori JR;Halder M;Xu Y;Kabgani N;Kaesler N;Klaus M;Gernhold L;Puelles VG;Huber TB;Boor P;Menzel S;Hoogenboezem RM;Bindels EMJ;Steffens J;Floege J;Schneider RK;Saez-Rodriguez J;Henderson NC;Kramann R
通讯作者：
Kramann R
影响因子：
4.6
作者：
Liu, Hongbing;Chen, Shaowei;El-Dahr, Samir S.
通讯作者：
El-Dahr, Samir S.
DOI：
10.1515/1544-6115.1826
发表时间：
2012-01-01
影响因子：
0.9
作者：
Lund, Steven P.;Nettleton, Dan;Smyth, Gordon K.
通讯作者：
Smyth, Gordon K.