Host responses in tissue repair and fibrosis.
Host responses in tissue repair and fibrosis.
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DOI：
10.1146/annurev-pathol-020712-163930
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发表时间：
2013-01-24
期刊：
影响因子：
--
通讯作者：
Wynn TA
中科院分区：
文献类型：
--
作者：
Duffield JS;Lupher M;Thannickal VJ;Wynn TA
肌成纤维细胞积聚在器官结构之间的空间中，并产生细胞外基质（ECM）蛋白，包括胶原蛋白I。它们是组织重塑和纤维化中的主要“效应”细胞。以前，被称为纤维细胞和肌成纤维细胞的白细胞祖细胞通过上皮-间充质转化（EMT）从上皮细胞产生，被认为是损伤组织中产生ECM的肌成纤维细胞的主要来源。然而，遗传命运作图实验表明，间充质来源的细胞，称为常驻成纤维细胞，和周细胞是瘢痕形成肌成纤维细胞的主要前体，而上皮细胞，内皮细胞和骨髓白细胞主要通过产生关键的纤维化细胞因子和促进细胞间通讯来促进纤维化。来源于T细胞、巨噬细胞和其他骨髓细胞群体的许多细胞因子是肌成纤维细胞分化的重要驱动因素。单核细胞衍生的细胞群是纤维化过程的关键调节因子：它们在驱动纤维化的过程中起制动作用，并且它们拆除和降解已建立的纤维化。我们讨论了肌成纤维细胞在各种重要的纤维化疾病中的起源、激活模式和命运，并描述了如何操纵巨噬细胞激活来帮助改善纤维化。
Myofibroblasts accumulate in the spaces between organ structures and produce extracellular matrix (ECM) proteins, including collagen I. They are the primary “effector” cells in tissue remodeling and fibrosis. Previously, leukocyte progenitors termed fibrocytes and myofibroblasts generated from epithelial cells through epithelial-to-mesenchymal transition (EMT) were considered the primary sources of ECM-producing myofibroblasts in injured tissues. However, genetic fate mapping experiments suggest that mesenchyme-derived cells, known as resident fibroblasts, and pericytes are the primary precursors of scar-forming myofibroblasts, whereas epithelial cells, endothelial cells, and myeloid leukocytes contribute to fibrogenesis predominantly by producing key fibrogenic cytokines and by promoting cell-to-cell communication. Numerous cytokines derived from T cells, macrophages, and other myeloid cell populations are important drivers of myofibroblast differentiation. Monocyte-derived cell populations are key regulators of the fibrotic process: They act as a brake on the processes driving fibrogenesis, and they dismantle and degrade established fibrosis. We discuss the origins, modes of activation, and fate of myofibroblasts in various important fibrotic diseases and describe how manipulation of macrophage activation could help ameliorate fibrosis.
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DOI：
10.1152/ajpheart.00928.2007
发表时间：
2007-12-01
影响因子：
4.8
作者：
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影响因子：
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DOI：
10.1016/s0022-5320(83)90133-8
发表时间：
1983-01-01
期刊：
JOURNAL OF ULTRASTRUCTURE RESEARCH
影响因子：
--
作者：
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