The cortisol awakening response and anterior cingulate cortex function in maltreated depressed versus non-maltreated depressed youth.
The cortisol awakening response and anterior cingulate cortex function in maltreated depressed versus non-maltreated depressed youth.
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DOI：
10.1016/j.psyneuen.2017.09.001
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发表时间：
2017-12
影响因子：
3.7
通讯作者：
Anker JJ
中科院分区：
文献类型：
--
作者：
Quevedo K;Doty J;Roos L;Anker JJ
经历过（与没有经历过）虐待的儿童的抑郁症状更严重，对传统治疗更有抵抗力，并与自杀风险增加有关。最近的证据表明，压力调节系统的扰动和负面自我评价的提高是增加抑郁虐待（与非虐待）青年所经历的精神病理学严重程度的因素。这些差异的可能解释机制是下丘脑-垂体轴（HPA）功能紊乱和持续的负性自我参照偏见，这些偏见受到前额叶皮层功能（包括背侧前扣带皮层（dACC））的支持。在自我评价任务中，收集了虐待和非虐待抑郁青年的皮质醇觉醒反应（CAR）和dACC的功能。采用分层线性模型对CAR进行建模。虐待组、积极和消极自我评价时的dACC功能以及其他关键预测因素均被纳入模型。事后分析探讨了显著差异的解释。与未受虐待的青年相比，受虐待的抑郁青年表现出更高的CAR。在低水平的dACC活动过程中处理的负面自我描述虐待和非虐待抑郁青年的CAR没有差异。然而，在处理消极的自我描述时，在dACC活性水平升高的情况下，虐待抑郁青年的CAR显著高于非虐待抑郁青年。
Symptomatology of depression among children who have (vs. have not) experienced maltreatment is greater in severity, more resistant to conventional treatment, and associated with elevated risk for suicide. Recent evidence implicates perturbations in stress regulatory systems and heightened negative self-appraisals as factors that increase the severity of psychopathology experienced by depressed maltreated (vs. non-maltreated) youth. Likely explanatory mechanisms for these differences are disturbances in the function of the hypothalamic-pituitary axis (HPA) and persistent negative self-referential biases supported by prefrontal cortex function including the dorsal anterior cingulate cortex (dACC). The cortisol awakening response (CAR) and the function of the dACC during a self-appraisal task were collected in maltreated and non-maltreated depressed youth. Hierarchical linear models were employed to model the CAR. Maltreatment group, dACC function during positive and negative self-appraisals as well as other key predictors, were included in the models. Post hoc analyses explored explanations for significant differences. Maltreated depressed youth exhibited a higher CAR compared to non-maltreated youth. At low levels of dACC activity during processing of negative self-descriptors maltreated and non-maltreated depressed youth’s CAR did not differ. However, at elevated levels of dACC activity during processing of negative self-descriptors maltreated depressed youth exhibited significantly higher CAR compared to non-maltreated depressed youth.
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影响因子：
1.1
作者：
Dube, Shanta R;Anda, Robert F;Williamson, David F
通讯作者：
Williamson, David F
DOI：
10.1097/00004583-199709000-00016
发表时间：
1997-09-01
影响因子：
13.3
作者：
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Harakal, T
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4.8
作者：
Cohen, Judith A.;Berliner, Lucy;Mannarino, Anthony
通讯作者：
Mannarino, Anthony
影响因子：
10.6
作者：
Dannlowski, Udo;Stuhrmann, Anja;Kugel, Harald
通讯作者：
Kugel, Harald