Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases

Hydrogen Sulfide Plays an Important Protective Role through Influencing Endoplasmic Reticulum Stress in Diseases
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硫化氢通过影响疾病中的内质网应激发挥重要的保护作用

DOI:
10.7150/ijbs.38143
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发表时间:
2020-01
影响因子:
9.2
通讯作者:
Huiyang Liu
Huiyang Liu
中科院分区:
生物学2区
文献类型:
--
作者:
Honggang Wang;Xingzhuo Shi;Mengyuan Qiu;Shuangyu Lv;Huiyang Liu

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内质网是一个重要的细胞器,负责蛋白质的合成,修饰,折叠,组装和运输新的肽链。当内质网蛋白质折叠能力受损时,未折叠或错误折叠的蛋白质积累导致内质网应激。硫化氢是一种重要的信号分子,调节许多生理和病理过程。近年来的研究表明,H2S通过影响内质网应激在许多疾病中发挥重要的保护作用,但其机制尚不完全清楚。本文综述了近年来H2S对内质网应激的影响及其参与疾病机制的研究进展,为深入研究提供理论依据。
The endoplasmic reticulum is an important organelle responsible for protein synthesis, modification, folding, assembly and transport of new peptide chains. When the endoplasmic reticulum protein folding ability is impaired, the unfolded or misfolded proteins accumulate to lead to endoplasmic reticulum stress. Hydrogen sulfide is an important signaling molecule that regulates many physiological and pathological processes. Recent studies indicate that H2S plays an important protective role in many diseases through influencing endoplasmic reticulum stress, but its mechanism is not fully understood. This article reviewed the progress about the effect of H2S on endoplasmic reticulum stress and its mechanisms involved in diseases in recent years to provide theoretical basis for in-depth study.
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