Chemotherapy-Response Monitoring of Breast Cancer Patients Using Quantitative Ultrasound-Based Intra-Tumour Heterogeneities.
Chemotherapy-Response Monitoring of Breast Cancer Patients Using Quantitative Ultrasound-Based Intra-Tumour Heterogeneities.
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DOI：
10.1038/s41598-017-09678-0
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发表时间：
2017-09-04
影响因子：
4.6
通讯作者：
Czarnota GJ
中科院分区：
文献类型：
--
作者：
Sadeghi-Naini A;Sannachi L;Tadayyon H;Tran WT;Slodkowska E;Trudeau M;Gandhi S;Pritchard K;Kolios MC;Czarnota GJ
包括化疗在内的抗癌疗法旨在诱导肿瘤细胞死亡。细胞死亡引起细胞形态和组织微结构的改变，导致组织回声发生可测量的变化。本研究调查了定量超声（QUS）参数成像的有效性，以表征肿瘤内异质性和监测乳腺癌化疗的病理反应在一个大的患者队列（n = 100）。结果表明，QUS成像可以无创监测乳腺癌患者化疗后早期的病理反应和结果。具体而言，量化声学散射体的大小、浓度和间距的空间异质性的QUS生物标志物可以预测患者的治疗反应，交叉验证的准确度为82 ± 0.7%、86 ± 0.7%和85 ± 0.9%，受试者工作特征（ROC）曲线下面积为0.75 ± 0.1，治疗开始后1、4和8周分别为0.80 ± 0.1和0.89 ± 0.1。使用QUS生物标志物分类为应答者和非应答者的患者表现出显著不同的生存率，与临床和病理终点一致。这些结果形成了使用与生存相关的患者反应的早期预测信息的基础，以促进在个体患者的基础上适应标准抗癌治疗。
Anti-cancer therapies including chemotherapy aim to induce tumour cell death. Cell death introduces alterations in cell morphology and tissue micro-structures that cause measurable changes in tissue echogenicity. This study investigated the effectiveness of quantitative ultrasound (QUS) parametric imaging to characterize intra-tumour heterogeneity and monitor the pathological response of breast cancer to chemotherapy in a large cohort of patients (n = 100). Results demonstrated that QUS imaging can non-invasively monitor pathological response and outcome of breast cancer patients to chemotherapy early following treatment initiation. Specifically, QUS biomarkers quantifying spatial heterogeneities in size, concentration and spacing of acoustic scatterers could predict treatment responses of patients with cross-validated accuracies of 82 ± 0.7%, 86 ± 0.7% and 85 ± 0.9% and areas under the receiver operating characteristic (ROC) curve of 0.75 ± 0.1, 0.80 ± 0.1 and 0.89 ± 0.1 at 1, 4 and 8 weeks after the start of treatment, respectively. The patients classified as responders and non-responders using QUS biomarkers demonstrated significantly different survivals, in good agreement with clinical and pathological endpoints. The results form a basis for using early predictive information on survival-linked patient response to facilitate adapting standard anti-cancer treatments on an individual patient basis.
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影响因子：
50.5
作者：
Cleator, SJ;Makris, A;Powles, TJ
通讯作者：
Powles, TJ
DOI：
10.1016/s0889-8588(05)70065-4
发表时间：
1999-04-01
影响因子：
2.4
作者：
Esteva, FJ;Hortobagyi, GN
通讯作者：
Hortobagyi, GN
影响因子：
2.6
作者：
Ganeshan, B.;Skogen, K.;Miles, K.
通讯作者：
Miles, K.
影响因子：
3.8
作者：
Duric, N;Littrup, P;Duncan, R
通讯作者：
Duncan, R
DOI：
10.1109/tsmc.1973.4309314
发表时间：
1973-01-01
期刊：
IEEE TRANSACTIONS ON SYSTEMS MAN AND CYBERNETICS
影响因子：
--
作者：
HARALICK, RM;SHANMUGAM, K;DINSTEIN, I
通讯作者：
DINSTEIN, I