Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials.
Transient Receptor Potential (TRP) Channels in Head-and-Neck Squamous Cell Carcinomas: Diagnostic, Prognostic, and Therapeutic Potentials.
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DOI：
10.3390/ijms21176374
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发表时间：
2020-09-02
影响因子：
5.6
通讯作者：
Helyes Z
中科院分区：
文献类型：
--
作者：
Kiss F;Pohóczky K;Szállási A;Helyes Z
头颈部鳞状细胞癌(HNSCC)仍然是世界范围内癌症发病率和死亡率的主要原因。这是一种基本上可以预防的疾病，吸烟、酗酒和人类乳头瘤病毒(HPV)是主要的危险因素。然而，许多患者被诊断为晚期疾病，在过去的十年里，口腔鳞状细胞癌的存活率没有得到改善。显然，需要新的诊断和预后标记物来进行早期诊断和指导治疗。基因表达研究提示瞬时受体电位(Trp)通道参与了HNSCC的发病。TRPs在正常的上皮细胞中表达，在增殖和分化中起关键作用。越来越多的证据表明，HNSCC中Trp通道的表达可能发生改变，对HNSCC的诊断、预后和治疗具有重要意义。在这篇综述中，我们认为Trp通道的表达可能为HNSCC的早期诊断和靶向分子治疗提供新的机会。
Head-and-neck squamous cell carcinomas (HNSCC) remain a leading cause of cancer morbidity and mortality worldwide. This is a largely preventable disease with smoking, alcohol abuse, and human papilloma virus (HPV) being the main risk factors. Yet, many patients are diagnosed with advanced disease, and no survival improvement has been seen for oral SCC in the past decade. Clearly, new diagnostic and prognostic markers are needed for early diagnosis and to guide therapy. Gene expression studies implied the involvement of transient receptor potential (TRP) channels in the pathogenesis of HNSCC. TRPs are expressed in normal epithelium where they play a key role in proliferation and differentiation. There is increasing evidence that the expression of TRP channels may change in HNSCC with important implications for diagnosis, prognosis, and therapy. In this review, we propose that TRP channel expression may afford a novel opportunity for early diagnosis of HNSCC and targeted molecular treatment.
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影响因子：
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