Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function.
Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function.
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姜黄素通过改善 PPAR-γ 功能来保护神经元免受脑缺血引起的炎症。
DOI：
10.1155/2013/470975
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Jiao JS
中科院分区：
文献类型：
--
作者：
Liu ZJ;Liu W;Liu L;Xiao C;Wang Y;Jiao JS
脑缺血是世界范围内最常见的脑血管病。近年来的研究表明姜黄素具有减轻脑缺血损伤的作用。然而，目前还不清楚姜黄素如何保护脑缺血损伤。本研究采用大鼠大脑中动脉闭塞模型，发现姜黄素是一种有效的过氧化物酶体增殖物激活物受体γ激动剂，它能上调过氧化物酶体增殖物受体γ的表达和过氧化物酶体增殖物受体γ-PPRE结合活性。姜黄素能明显缩小大鼠脑梗死体积，改善神经功能缺损，减轻神经元损伤。此外，姜黄素还可通过降低炎症介质IL-1β、TNF-α、PGE 2、NO、考克斯-2、iNOS等抑制脑缺血后神经炎症反应。姜黄素还能抑制脑缺血引起的IκB降解。本研究还表明，PPARγ与NF-κB-p65相互作用，抑制NF-κB的活化。PPARγ抑制剂GW 9662可明显减弱姜黄素的上述脑保护作用。上述结果提示，姜黄素诱导的PPARγ可能通过抑制炎症反应在脑损伤保护中发挥重要作用。它还强调了姜黄素作为脑缺血治疗剂的潜力。
Cerebral ischemia is the most common cerebrovascular disease worldwide. Recent studies have demonstrated that curcumin had beneficial effect to attenuate cerebral ischemic injury. However, it is unclear how curcumin protects against cerebral ischemic injury. In the present study, using rat middle cerebral artery occlusion model, we found that curcumin was a potent PPARγ agonist in that it upregulated PPARγ expression and PPARγ-PPRE binding activity. Administration of curcumin markedly decreased the infarct volume, improved neurological deficits, and reduced neuronal damage of rats. In addition, curcumin suppressed neuroinflammatory response by decreasing inflammatory mediators, such as IL-1β, TNF-α, PGE2, NO, COX-2, and iNOS induced by cerebral ischemia of rats. Furthermore, curcumin suppressed IκB degradation that was caused by cerebral ischemia. The present data also showed that PPARγ interacted with NF-κB-p65 and thus inhibited NF-κB activation. All the above protective effects of curcumin on cerebral ischemic injury were markedly attenuated by GW9662, an inhibitor of PPARγ. Our results as described above suggested that PPARγ induced by curcumin may play a critical role in protecting against brain injury through suppression of inflammatory response. It also highlights the potential of curcumin as a therapeutic agent against cerebral ischemia.
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影响因子：
9.3
作者：
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通讯作者：
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3.3
作者：
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