The preterm human milk microbiota fluctuates by postpartum week and is characterized by gestational age and maternal BMI.
The preterm human milk microbiota fluctuates by postpartum week and is characterized by gestational age and maternal BMI.
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DOI：
10.1128/mbio.02106-23
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发表时间：
2023-12-19
期刊：
影响因子：
6.4
通讯作者：
Gregory, Katherine E.
中科院分区：
文献类型：
--
作者：
Filatava, Evgenia Jen;Liu, Zhongmao;Xie, Jiaojiao;Tran, Dong-Binh;Chen, Kun;El Habbal, Noura;Weinstock, George;Zhou, Yanjiao;Gregory, Katherine E.
关键词：
有证据表明，喂养早产儿的营养类型会影响他们的肠道微生物组和免疫力。然而，很少有研究对母乳中的微生物群及其构成因素进行纵向分析。此外，巴氏灭菌的供体人乳（PDHM）和婴儿配方奶粉的微生物群尚未得到广泛研究。在这里，我们使用16 S rRNA测序检查了来自72名早产儿队列的238个婴儿，30个PDHM和73个配方奶粉样本的微生物群。我们发现营养类型之间的微生物多样性和组成的差异。此外，我们还证明了胎儿的微生物群表现出时间波动，并与几个母体因素有关。最后，我们确定了三个微生物群落集群内的MOM-称为乳糖型-有不同的分类组成和母体因素。总的来说，我们的研究结果为探索营养微生物群与早产儿健康结果之间的关系奠定了基础。尽管越来越多的人认识到早产儿接受的营养类型会影响他们的肠道微生物组和健康结果，但母乳（母乳），巴氏灭菌供体母乳（PDHM）和婴儿配方奶粉的微生物群仍然缺乏特征。在我们的研究中，我们发现，微生物群落结构，细菌多样性，以及特定属的相对丰度之间的显着差异，PDHM，配方。此外，我们的研究结果表明，胎儿的微生物群随着时间和母体因素的变化而变化。最后，我们确定了三个乳型内有不同的微生物组成，并描述了与它们相关的母体因素。这些发现为未来的研究奠定了基础，旨在提高我们对早产儿营养微生物群及其可能对健康结果产生的具体影响的认识。
Evidence suggests that the type of nutrition fed to preterm infants influences their intestinal microbiome and immunity. However, few studies have conducted a longitudinal analysis of the microbiota of mother’s own milk (MOM) and the factors shaping its composition. Furthermore, the microbiota of pasteurized donor human milk (PDHM) and infant formula have not been extensively investigated. Here, we examine the microbiota of 238 MOM, 30 PDHM, and 73 formula samples from a cohort of 72 preterm infants using 16S rRNA sequencing. We find differences in the microbial diversity and composition between nutrition types. Additionally, we demonstrate that the microbiota of MOM exhibits temporal fluctuations and has associations with several maternal factors. Lastly, we identify three microbiota community clusters within MOM—termed lactotypes—that have distinct taxonomic compositions and maternal factors. Collectively, our findings lay the foundation for exploring the relationship between the microbiota of nutrition and preterm infant health outcomes. Despite a growing recognition that the type of nutrition received by preterm infants influences their intestinal microbiome and health outcomes, the microbiota of mother's own milk (MOM), pasteurized donor human milk (PDHM), and infant formula remain poorly characterized. In our study, we found that the structure of microbial communities, bacterial diversity, and relative abundances of specific genera were significantly different between MOM, PDHM, and formula. Additionally, our results suggest that the microbiota of MOM changes as a function of time and maternal factors. Lastly, we identified three lactotypes within MOM that have distinct microbial compositions and described the maternal factors associated with them. These findings set the stage for future research aimed at advancing our knowledge of the microbiota of preterm infant nutrition and the specific influence it may have on health outcomes.
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影响因子：
5.2
作者：
Biagi E;Aceti A;Quercia S;Beghetti I;Rampelli S;Turroni S;Soverini M;Zambrini AV;Faldella G;Candela M;Corvaglia L;Brigidi P
通讯作者：
Brigidi P
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
2.7
作者：
Landers, Susan;Updegrove, Kim
通讯作者：
Updegrove, Kim
影响因子：
3.6
作者：
Jost, Ted;Lacroix, Christophe;Chassard, Christophe
通讯作者：
Chassard, Christophe
影响因子：
15.5
作者：
Davis, Nicole M;Proctor, Diana M;Callahan, Benjamin J
通讯作者：
Callahan, Benjamin J