COVID-19-Induced New-Onset Diabetes: Trends and Technologies.
COVID-19-Induced New-Onset Diabetes: Trends and Technologies.
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DOI：
10.2337/dbi21-0029
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发表时间：
2021-12
期刊：
影响因子：
7.7
通讯作者：
Snyder MP
中科院分区：
文献类型：
--
作者：
Metwally AA;Mehta P;Johnson BS;Nagarjuna A;Snyder MP
2019冠状病毒病（COVID-19）全球大流行继续在全球蔓延，迄今约有2. 16亿例确诊病例和449万例死亡。目前正在加紧努力，通过抑制病毒传播、了解其发病机制、制定疫苗接种战略和确定有效的治疗靶点来防治这种疾病。既存糖尿病的个体在感染后也表现出更高的COVID-19疾病发病率和更差的预后。同样，据报道，在COVID-19诊断后的患者中，糖尿病发作和糖尿病并发症的频率增加。COVID-19可能会增加有和没有糖尿病病史的患者发生高血糖症和其他并发症的风险。目前还不清楚该病毒是否会诱导1型或2型糖尿病，或者导致一种新型的非典型糖尿病。此外，目前尚不清楚康复中的COVID-19患者是否会表现出更高的新发糖尿病或其并发症风险。本综述的目的是总结目前已知的COVID-19和糖尿病之间双向关系的流行病学和机制。我们强调了阻碍COVID-19诱导的新发糖尿病研究的主要挑战，并提出了克服这些障碍的潜在框架。我们还回顾了最先进的可穿戴设备和微采样技术，这些技术可以进一步研究新发糖尿病病例的糖尿病管理和进展。最后，我们概述了目前调查COVID-19和糖尿病之间双向关系的研究计划，其中一些重点是可穿戴技术。
The coronavirus disease 2019 (COVID-19) global pandemic continues to spread worldwide with approximately 216 million confirmed cases and 4.49 million deaths to date. Intensive efforts are ongoing to combat this disease by suppressing viral transmission, understanding its pathogenesis, developing vaccination strategies, and identifying effective therapeutic targets. Individuals with preexisting diabetes also show higher incidence of COVID-19 illness and poorer prognosis upon infection. Likewise, an increased frequency of diabetes onset and diabetes complications has been reported in patients following COVID-19 diagnosis. COVID-19 may elevate the risk of hyperglycemia and other complications in patients with and without prior diabetes history. It is unclear whether the virus induces type 1 or type 2 diabetes or instead causes a novel atypical form of diabetes. Moreover, it remains unknown if recovering COVID-19 patients exhibit a higher risk of developing new-onset diabetes or its complications going forward. The aim of this review is to summarize what is currently known about the epidemiology and mechanisms of this bidirectional relationship between COVID-19 and diabetes. We highlight major challenges that hinder the study of COVID-19–induced new-onset of diabetes and propose a potential framework for overcoming these obstacles. We also review state-of-the-art wearables and microsampling technologies that can further study diabetes management and progression in new-onset diabetes cases. We conclude by outlining current research initiatives investigating the bidirectional relationship between COVID-19 and diabetes, some with emphasis on wearable technology.
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