γδ T cells: origin and fate, subsets, diseases and immunotherapy.
γδ T cells: origin and fate, subsets, diseases and immunotherapy.
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γδ T细胞：起源和命运，亚群，疾病和免疫治疗。
DOI：
10.1038/s41392-023-01653-8
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发表时间：
2023-11-22
影响因子：
39.3
通讯作者：
Wu, Yangzhe
中科院分区：
文献类型：
--
作者：
Hu, Yi;Hu, Qinglin;Li, Yongsheng;Lu, Ligong;Xiang, Zheng;Yin, Zhinan;Kabelitz, Dieter;Wu, Yangzhe
疾病的复杂性是由免疫系统耗竭和过度激活等内在过程形成的，这突出了免疫重整作为一种有前途的疾病治疗策略的潜力。近年来，我们的主要焦点集中在基于γδ T细胞的免疫治疗上，特别是开创性地使用异体Vδ2+ γδ T细胞治疗晚期实体瘤和结核病患者。然而，我们认识到在免疫治疗中充分利用γδ T细胞效应功能的潜力和优化机会尚未开发。本文就γδ T细胞免疫学及其在疾病中的作用作一综述。首先，我们阐明了γδ T细胞和αβ T细胞之间的功能差异。我们还提供了自1984年发现γδ T细胞以来研究的主要里程碑的概述。此外，我们还深入研究了控制它们的起源、发展、命运决定和胸腺内T细胞受体（TCR）重排的复杂生物学过程。通过研究基于γδ tcr结构或细胞因子释放的不同γδT细胞亚型抗肿瘤功能的机制，我们强调准确的亚型对理解γδT细胞功能的重要性。我们还探讨了γδ T细胞亚群的微环境依赖性功能，特别是在感染性疾病、自身免疫性疾病、血液恶性肿瘤和实体肿瘤中。最后，我们提出了利用异体γδ T细胞进行肿瘤免疫治疗的未来策略。通过这篇全面的综述，我们的目标是让读者对γδ T细胞的分子基础和转化研究前沿有一个全面的了解，最终有助于进一步利用γδ T细胞的治疗潜力。
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering the use of allogeneic Vδ2+ γδ T cells for treating late-stage solid tumors and tuberculosis patients. However, we recognize untapped potential and optimization opportunities to fully harness γδ T cell effector functions in immunotherapy. This review aims to thoroughly examine γδ T cell immunology and its role in diseases. Initially, we elucidate functional differences between γδ T cells and their αβ T cell counterparts. We also provide an overview of major milestones in γδ T cell research since their discovery in 1984. Furthermore, we delve into the intricate biological processes governing their origin, development, fate decisions, and T cell receptor (TCR) rearrangement within the thymus. By examining the mechanisms underlying the anti-tumor functions of distinct γδ T cell subtypes based on γδTCR structure or cytokine release, we emphasize the importance of accurate subtyping in understanding γδ T cell function. We also explore the microenvironment-dependent functions of γδ T cell subsets, particularly in infectious diseases, autoimmune conditions, hematological malignancies, and solid tumors. Finally, we propose future strategies for utilizing allogeneic γδ T cells in tumor immunotherapy. Through this comprehensive review, we aim to provide readers with a holistic understanding of the molecular fundamentals and translational research frontiers of γδ T cells, ultimately contributing to further advancements in harnessing the therapeutic potential of γδ T cells.
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DOI：
10.1084/jem.20181960
发表时间：
2018-12-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Jameson JM
通讯作者：
Jameson JM
DOI：
10.7759/cureus.10301
发表时间：
2020-09-07
期刊：
Cureus
影响因子：
--
作者：
Hoard R;Shahin G;Andreca FD;Osswald M
通讯作者：
Osswald M
气溶胶胰岛素诱导调节性CD8伽马三角细胞，可预防鼠胰岛素依赖性糖尿病。
DOI：
10.1084/jem.184.6.2167
发表时间：
1996-12-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Harrison LC;Dempsey-Collier M;Kramer DR;Takahashi K
通讯作者：
Takahashi K
影响因子：
30.5
作者：
Alves de Lima K;Rustenhoven J;Da Mesquita S;Wall M;Salvador AF;Smirnov I;Martelossi Cebinelli G;Mamuladze T;Baker W;Papadopoulos Z;Lopes MB;Cao WS;Xie XS;Herz J;Kipnis J
通讯作者：
Kipnis J
影响因子：
5.8
作者：
Altvater, Bianca;Pscherer, Sibylle;Rossig, Claudia
通讯作者：
Rossig, Claudia