Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I.
Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I.
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Cyclin B2 可以补偿卵母细胞减数分裂 I 中的 Cyclin B1
DOI：
10.1083/jcb.201802077
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发表时间：
2018-11-05
期刊：
影响因子：
--
通讯作者：
Liu YX
中科院分区：
文献类型：
--
作者：
Li J;Tang JX;Cheng JM;Hu B;Wang YQ;Aalia B;Li XY;Jin C;Wang XX;Deng SL;Zhang Y;Chen SR;Qian WP;Sun QY;Huang XX;Liu YX
Cyclin B1 and its interaction with CDK1 are thought to be critical for meiosis I progression in oocytes. However, using oocyte-specific conditional knockouts, Li et al. show that Cyclin B2 activity can compensate for Cyclin B1 to trigger meiosis resumption. Mammalian oocytes are arrested at the prophase of the first meiotic division for months and even years, depending on species. Meiotic resumption of fully grown oocytes requires activation of M-phase–promoting factor (MPF), which is composed of Cyclin B1 and cyclin-dependent kinase 1 (CDK1). It has long been believed that Cyclin B1 synthesis/accumulation and its interaction with CDK1 is a prerequisite for MPF activation in oocytes. In this study, we revealed that oocyte meiotic resumption occurred in the absence of Cyclin B1. Ccnb1-null oocytes resumed meiosis and extruded the first polar body. Without Cyclin B1, CDK1 could be activated by up-regulated Cyclin B2. Ccnb1 and Ccnb2 double knockout permanently arrested the oocytes at the prophase of the first meiotic division. Oocyte-specific Ccnb1-null female mice were infertile due to failed MPF activity elevation and thus premature interphase-like stage entry in the second meiotic division. These results have revealed a hidden compensatory mechanism between Cyclin B1 and Cyclin B2 in regulating MPF and oocyte meiotic resumption.
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DOI：
10.1073/pnas.94.2.502
发表时间：
1997-01-21
影响因子：
11.1
作者：
Li, J;Meyer, AN;Donoghue, DJ
通讯作者：
Donoghue, DJ
影响因子：
21.3
作者：
通讯作者：
--
影响因子：
11.8
作者：
Gui, Liming;Homer, Hayden
通讯作者：
Homer, Hayden
影响因子：
1.7
作者：
Huo, LJ;Yu, LZ;Sun, QY
通讯作者：
Sun, QY
DOI：
10.1007/978-1-62703-191-2_6
发表时间：
2013-01-01
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Holt, Janet E;Lane, Simon I R;Jones, Keith T
通讯作者：
Jones, Keith T