Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges.
Translational considerations in injectable cell-based therapeutics for neurological applications: concepts, progress and challenges.
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DOI：
10.1038/s41536-017-0028-x
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发表时间：
2017
影响因子：
7.2
通讯作者：
White LJ
中科院分区：
文献类型：
--
作者：
Amer MH;Rose FRAJ;Shakesheff KM;Modo M;White LJ
过去十年中，细胞疗法的临床应用取得了重大进展。然而，现有的细胞递送方法取得的成功有限，大量研究表明，在移植后几天内，只有不到 5% 的注射细胞能够在注射部位持续存在。尽管越来越多地考虑临床试验设计，但很少强调用于管理细胞的工具和方案。各种细胞类型的不同行为、剂量准确性、精确递送以及注射后细胞保留和活力是临床转化面临的一些障碍。为了有效地进行可注射细胞移植，需要准确表征注射后的细胞健康状况并制定标准化的管理方案。这篇综述概述了细胞疗法的有效传递所面临的挑战，审查了为研究可注射细胞传递而进行的关键研究，并概述了将这些发现转化为更有效的细胞治疗干预措施的机会。
Significant progress has been made during the past decade towards the clinical adoption of cell-based therapeutics. However, existing cell-delivery approaches have shown limited success, with numerous studies showing fewer than 5% of injected cells persisting at the site of injection within days of transplantation. Although consideration is being increasingly given to clinical trial design, little emphasis has been given to tools and protocols used to administer cells. The different behaviours of various cell types, dosing accuracy, precise delivery, and cell retention and viability post-injection are some of the obstacles facing clinical translation. For efficient injectable cell transplantation, accurate characterisation of cellular health post-injection and the development of standardised administration protocols are required. This review provides an overview of the challenges facing effective delivery of cell therapies, examines key studies that have been carried out to investigate injectable cell delivery, and outlines opportunities for translating these findings into more effective cell-therapy interventions.
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