Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese.
Association study of a genetic variant in the long intergenic noncoding RNA (linc01080) with schizophrenia in Han Chinese.
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DOI：
10.1186/s12888-021-03623-2
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发表时间：
2021-12-08
期刊：
影响因子：
4.4
通讯作者：
Luo X
中科院分区：
文献类型：
--
作者：
Qi Y;Wei Y;Yu F;Lin Q;Yin J;Fu J;Xiong S;Lv D;Dai Z;Peng Q;Wang Y;Zhang D;Wang L;Ye X;Lin Z;Lin J;Ma G;Li K;Luo X
精神分裂症目前被认为是一种病因不明的多基因相关疾病。本研究将验证长基因间非编码RNA01080 （linc01080）的单核苷酸多态性（SNP）是否与精神分裂症的易感性和表型异质性有关，以期为该病的预防和个体化治疗提供数据支持。采用改良的多重结扎检测反应（imLDR）技术，对中国南方汉族人群中1139例精神分裂症患者和1039例对照者的linc01080 SNP rs7990916进行基因分型。同时，我们评估和分析了该SNP与精神分裂症患者临床症状和认知功能之间的关系。两组间基因型分布、等位基因频率分布、性别分层分析均无显著差异。然而，rs7990916的SNP与精神分裂症患者的发病年龄显著相关（P = 8.22E-07），携带T等位基因的患者比携带CC基因型的患者发病年龄更早。认知功能方面，携带T等位基因的患者在认知简要评估（BACS）中的伦敦塔评分和符号编码评分均低于CC基因型携带者，差异有统计学意义（P = 0.014, P = 0.022）。我们的数据首次表明，linc01080多态性可能影响精神分裂症患者的发病年龄和神经认知功能。
Schizophrenia is currently considered to be a polygene-related disease with unknown etiology. This research will verify whether the single nucleotide polymorphism (SNP) of the long intergenic noncoding RNA01080 (linc01080) contributes to the susceptibility and phenotypic heterogeneity of schizophrenia, with a view to providing data support for the prevention and individualized treatment of this disease. The SNP rs7990916 in linc01080 were genotyped in 1139 schizophrenic and 1039 controls in a Southern Chinese Han population by the improved multiplex ligation detection reaction (imLDR) technique. Meanwhile, we assessed and analyzed the association between this SNP and schizophrenics’ clinical symptoms, and the cognitive function. There was no significant difference in genotype distribution, allele frequency distribution, gender stratification analysis between the two groups. However, the SNP of rs7990916 was significantly associated with the age of onset in patients with schizophrenia (P = 8.22E-07), patients with T allele had earlier onset age compared with CC genotype carriers. In terms of cognitive function, patients with T allele scored lower than CC genotype carriers in the Tower of London score and symbol coding score in the Brief assessment of Cognition (BACS), and the difference was statistically significant (P = 0.014, P = 0.022, respectively). Our data show for the first time that linc01080 polymorphism may affect the age of onset and neurocognitive function in patients with schizophrenia.
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DOI：
10.1016/j.nicl.2016.06.002
发表时间：
2016
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Torres US;Duran FL;Schaufelberger MS;Crippa JA;Louzã MR;Sallet PC;Kanegusuku CY;Elkis H;Gattaz WF;Bassitt DP;Zuardi AW;Hallak JE;Leite CC;Castro CC;Santos AC;Murray RM;Busatto GF
通讯作者：
Busatto GF
影响因子：
6.7
作者：
Sakurai T;Gamo NJ;Hikida T;Kim SH;Murai T;Tomoda T;Sawa A
通讯作者：
Sawa A
影响因子：
6.6
作者：
Ehrlich, Stefan;Brauns, Stefan;Sponheim, Scott R.
通讯作者：
Sponheim, Scott R.
影响因子：
5.7
作者：
Honea R;Verchinski BA;Pezawas L;Kolachana BS;Callicott JH;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
6.8
作者：
Selemon LD;Zecevic N
通讯作者：
Zecevic N