Natural variation in plant telomere length is associated with flowering time.
Natural variation in plant telomere length is associated with flowering time.
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DOI：
10.1093/plcell/koab022
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发表时间：
2021-05-31
期刊：
影响因子：
--
通讯作者：
Purugganan MD
中科院分区：
文献类型：
--
作者：
Choi JY;Abdulkina LR;Yin J;Chastukhina IB;Lovell JT;Agabekian IA;Young PG;Razzaque S;Shippen DE;Juenger TE;Shakirov EV;Purugganan MD
端粒是在染色体末端发现的高度重复的DNA序列，其在细胞分裂期间保护染色体免于退化。在这里，使用全基因组重新测序和末端限制性片段测定，我们发现了大量的自然种内变异的端粒长度在拟南芥，水稻（水稻），玉米（玉米）。全基因组关联研究（GWAS）定位在A。thaliana鉴定了13个与GWAS显著相关的区域，这些区域是端粒长度变异的基础，包括一个携带端粒酶逆转录酶（TERT）基因的区域。群体基因组分析提供了选择性扫描与较长端粒相关的TERT区域的证据。我们发现，端粒长度与开花时间的变化呈负相关。这一发现不仅适用于拟南芥，也适用于玉米和水稻，表明生活史性状与染色体完整性之间存在联系。我们的研究结果指出了这种相关性的几个可能原因，包括较长的端粒可能在发育速度更快的植物中更具适应性（因此开花更早）。我们的工作表明，染色体结构本身可能是一个适应性状与植物生活史的战略。 端粒长度与拟南芥、水稻和玉米开花时间的变化有关。
Telomeres are highly repetitive DNA sequences found at the ends of chromosomes that protect the chromosomes from deterioration duringcell division. Here, using whole-genome re-sequencing and terminal restriction fragment assays, we found substantial natural intraspecific variation in telomere length in Arabidopsis thaliana, rice (Oryza sativa), and maize (Zea mays). Genome-wide association study (GWAS) mapping in A. thaliana identified 13 regions with GWAS-significant associations underlying telomere length variation, including a region that harbors the telomerase reverse transcriptase (TERT) gene. Population genomic analysis provided evidence for a selective sweep at the TERT region associated with longer telomeres. We found that telomere length is negatively correlated with flowering time variation not only in A. thaliana, but also in maize and rice, indicating a link between life-history traits and chromosome integrity. Our results point to several possible reasons for this correlation, including the possibility that longer telomeres may be more adaptive in plants that have faster developmental rates (and therefore flower earlier). Our work suggests that chromosomal structure itself might be an adaptive trait associated with plant life-history strategies. Telomere length is associated with flowering time variation in Arabidopsis, rice, and maize.
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影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
DOI：
10.1073/pnas.96.26.14813
发表时间：
1999-12-21
影响因子：
11.1
作者：
Fitzgerald, MS;Riha, K;Shippen, DE
通讯作者：
Shippen, DE
影响因子：
4.5
作者：
Bilinski, Paul;Albert, Patrice S.;Ross-Ibarra, Jeffrey
通讯作者：
Ross-Ibarra, Jeffrey
影响因子：
3.3
作者：
Flynn, Jullien M.;Caldas, Ian;Clark, Andrew G.
通讯作者：
Clark, Andrew G.
影响因子：
5
作者：
Fitzpatrick, Annette L.;Kronmal, Richard A.;Aviv, Abraham
通讯作者：
Aviv, Abraham