Autophagy as a target for development of anti-diabetes drugs derived from natural compounds
Autophagy as a target for development of anti-diabetes drugs derived from natural compounds
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自噬作为开发天然化合物抗糖尿病药物的目标
DOI：
10.1080/10286020.2017.1304929
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发表时间：
2017-03
影响因子：
1.7
通讯作者：
Hu Zhuo-Wei
中科院分区：
文献类型：
--
作者：
Zhang Xiao-Wei;Zhou Ji-Chao;Hu Zhuo-Wei
摘要糖尿病患者的血糖水平很高，因为他们的身体不能产生足够的胰岛素或对这种激素做出适当的反应。在这两种情况下，已经变得明显的是，持续高浓度的葡萄糖、胰岛素、胰岛素样生长因子和胰岛素抵抗导致胰岛细胞和涉及糖尿病并发症的其他器官（包括肝脏、心血管和神经系统）中的自噬活性的功能障碍和破坏。越来越多的证据表明，自噬是糖尿病治疗的一个新靶点，对糖尿病有广泛的治疗作用，许多药物和天然产物通过多种信号通路参与自噬的调节，诱导或抑制自噬。本文综述了近年来天然药物和天然化合物通过调节自噬对糖尿病及其并发症的作用，以期为进一步研究这些药物和化合物的作用机制和临床应用提供参考。
Abstract Patients with diabetes have a high level of blood glucose because their body cannot produce enough insulin or properly respond to this hormone. In both situations, it has become evident that persistent high concentrations of glucose, insulin, insulin-like growth factor, and insulin resistance lead to dysfunction and destruction of autophagic activity in the cells of islet and other organs involved in complications of diabetes, including the liver, cardiovascular, and nervous systems. Accumulating evidences have revealed that autophagy is a novel therapeutic target with a wide range of beneficial effects on diabetes and that plenty of drugs and natural products are involved in autophagy modulation, either inducing or inhibiting autophagy, through multiple signaling pathways. In this review, we summarize the roles of several clinical drugs and compounds derived from natural products in diabetes and its complications through regulation of autophagy, expecting to inspire further investigation of the underlying mechanisms of these compounds and to facilitate their better clinical application.
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影响因子：
7.7
作者：
Hardie DG
通讯作者：
Hardie DG
影响因子：
21.3
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作者：
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DOI：
10.1016/b978-0-12-803783-6.00006-7
发表时间：
2017-01-01
期刊：
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通讯作者：
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影响因子：
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