Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees.
Effect of walking on in vivo tibiofemoral cartilage strain in ACL-deficient versus intact knees.
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DOI：
10.1016/j.jbiomech.2020.110210
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发表时间：
2021-02-12
影响因子：
2.4
通讯作者：
DeFrate LE
中科院分区：
文献类型：
--
作者：
Crook BS;Collins AT;Lad NK;Spritzer CE;Wittstein JR;DeFrate LE
前交叉韧带（ACL）断裂改变膝关节运动学，并导致骨关节炎的过早发展。然而，关于ACL缺陷膝关节中胫股软骨对日常生活活动（ADL）的体内生物力学反应的数据有限。在这项研究中，8名患有慢性单侧ACL缺陷的健康受试者完成了一项应力测试，以评估以2.5 mph的速度进行20分钟的水平跑步机步行对ACL缺陷和对侧ACL完整膝关节胫股软骨的影响。根据损伤和未损伤膝关节活动前和活动后的磁共振（MR）图像建立的三维表面模型用于确定胫股软骨多个区域（胫骨平台内侧和外侧、股骨髁内侧和外侧、股骨髁内侧与股骨髁间窝相邻）的压缩应变。在ACL缺陷膝关节中，我们观察到与髁间窝相邻的内侧股骨髁区域（缺陷组6% vs.对侧2%，p=0.01）以及内侧和外侧胫骨平台（4% vs. 3%，p=0.01）的软骨应变相对于对侧ACL完好膝关节显著增加。内侧髁间窝和胫骨平台处的压缩应变增加表明这些区域的机械载荷或对载荷的反应发生变化，推测与膝关节运动学改变有关。这些变化可能会破坏软骨内稳态，并导致骨关节炎的后续发展。
Anterior cruciate ligament (ACL) rupture alters knee kinematics and contributes to premature development of osteoarthritis. However, there is limited data regarding the in vivo biomechanical response of tibiofemoral cartilage to activities of daily living (ADLs) in ACL-deficient knees. In this study, eight otherwise healthy participants with chronic unilateral ACL deficiency completed a stress test to assess the effect of 20 minutes of level treadmill walking at a speed of 2.5 mph on tibiofemoral cartilage in their ACL-deficient and contralateral ACL-intact knees. Three-dimensional surface models developed from pre- and post-activity magnetic resonance (MR) images of the injured and uninjured knees were used to determine compressive strain across multiple regions of tibiofemoral cartilage (medial and lateral tibial plateaus, medial and lateral femoral condyles, medial aspect of femoral condyle adjacent to intercondylar notch of the femur). In the ACL-deficient knees, we observed significantly increased cartilage strain in the region of the medial femoral condyle adjacent to the intercondylar notch (6% in deficient vs. 2% in contralateral, p=0.01) as well as across the medial and lateral tibial plateaus (4% vs. 3%, p=0.01) relative to the contralateral ACL-intact knees. Increased compressive strain at the medial intercondylar notch and tibial plateau suggests alterations in mechanical loading or the response to load in these regions, presumably related to altered knee kinematics. These changes may disrupt cartilage homeostasis and contribute to subsequent development of osteoarthritis.
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DOI：
10.1016/0020-1383(90)90130-m
发表时间：
1990-11-01
影响因子：
2.5
作者：
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通讯作者：
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影响因子：
3.3
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通讯作者：
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影响因子：
1.8
作者：
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通讯作者：
Zheng, Naiquan (Nigel)
影响因子：
1.9
作者：
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