Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications.
Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications.
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DOI：
10.1039/c7cs00492c
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发表时间：
2017-12-11
影响因子：
46.2
通讯作者：
Xia Y
中科院分区：
文献类型：
--
作者：
Zhu C;Xia Y
低密度脂蛋白（LDL）是体内脂质转运的四种主要脂蛋白之一，正在成为治疗诊断剂靶向递送的有吸引力的载体。与合成系统相比，LDL颗粒具有内在的生物相容性和生物可降解性，同时具有降低的免疫原性和天然的靶向癌细胞和逃避网状内皮系统识别和消除的能力。受这些属性的吸引，已经开发了许多策略用于重构LDL颗粒，包括与载脂蛋白缀合、插入磷脂层和装载到核心中。在这里，我们提出了一个教程审查的发展重组低密度脂蛋白（rLDL）颗粒的治疗诊断应用。我们首先简要介绍了LDL和LDL受体，以及使用rLDL颗粒作为靶向递送治疗诊断剂的天然和多功能平台的优势。在讨论了常用的LDL重建策略后，我们强调了rLDL颗粒在疾病进展分期、病变组织治疗和光动力癌症治疗中的应用。最后，我们展望了剩余的挑战和未来的发展方向。本教程回顾介绍了重组低密度脂蛋白的概念，有针对性地提供不同类型的治疗诊断剂。
Low-density lipoprotein (LDL), one of the four major groups of lipoproteins for lipid transport in vivo, is emerging as an attractive carrier for the targeted delivery of theranostic agents. In contrast to the synthetic systems, LDL particles are intrinsically biocompatible and biodegradable, together with reduced immunogenicity and natural capabilities to target cancerous cells and to escape from the recognition and elimination by the reticuloendothelial system. Enticed by these attributes, a number of strategies have been developed for reconstituting LDL particles, including conjugation to the apolipoprotein, insertion into the phospholipid layer, and loading into the core. Here we present a tutorial review on the development of reconstituted LDL (rLDL) particles for theranostic applications. We start with a brief introduction to LDL and LDL receptor, as well as the advantages of using rLDL particles as a natural and versatile platform for the targeted delivery of theranostic agents. After a discussion of commonly used strategies for the reconstitution of LDL, we highlight the applications of rLDL particles in the staging of disease progression, treatment of lesioned tissues, and delivery of photosensitizers for photodynamic cancer therapy. We finish this review with a perspective on the remaining challenges and future directions. This tutorial review introduces the concept of reconstituting low-density lipoprotein for the targeted delivery of different types of theranostic agents.
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影响因子：
14
作者：
Mulik RS;Bing C;Ladouceur-Wodzak M;Munaweera I;Chopra R;Corbin IR
通讯作者：
Corbin IR
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
18.3
作者：
Ng, Kenneth K.;Lovell, Jonathan F.;Zheng, Gang
通讯作者：
Zheng, Gang
DOI：
10.1002/jss.400100409
发表时间：
1979-01-01
期刊：
JOURNAL OF SUPRAMOLECULAR STRUCTURE
影响因子：
--
作者：
KRIEGER, M;SMITH, LC;BROWN, MS
通讯作者：
BROWN, MS
影响因子：
13.3
作者：
Lee, Jeong Yu;Kim, Jin-Ho;Nam, Yoon Sung
通讯作者：
Nam, Yoon Sung