Systemic tumor-specific gene delivery.
Systemic tumor-specific gene delivery.
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DOI：
10.1016/j.jconrel.2013.08.300
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发表时间：
2013-12-28
期刊：
影响因子：
--
通讯作者：
Anchordoquy TJ
中科院分区：
文献类型：
--
作者：
Kullberg M;McCarthy R;Anchordoquy TJ
全身施用的癌症基因疗法的目的是实现分离至肿瘤组织的基因表达。不幸的是，病毒系统对肝脏具有很强的亲和力，并且从非病毒阳离子系统递送通常导致在肺中的高表达。如果要用基因如激活肿瘤免疫应答的IL-12和可诱导肿瘤细胞凋亡的TNF-α积极治疗肿瘤，则必须克服向这些器官的非特异性递送。已经导致在肿瘤组织中特异性表达的技术包括通过配体缀合的受体靶向、利用肿瘤特异性启动子和病毒突变以利用在肿瘤细胞中过表达的蛋白质。本文分析了这些技术应用于脂质体，PEI，树枝状聚合物，干细胞和病毒基因传递系统，以确定系统给药后，最有效地实现肿瘤特异性基因表达的技术。
The objective of a systemically administered cancer gene therapy is to achieve gene expression that is isolated to the tumor tissue. Unfortunately, viral systems have strong affinity for the liver, and delivery from non-viral cationic systems often results in high expression in the lungs. Non-specific delivery to these organs must be overcome if tumors are to be aggressively treated with genes such as IL-12 which activates a tumor immune response, and TNF-alpha which can induce tumor cell apoptosis. Techniques which have led to specific expression in tumor tissue include receptor targeting through ligand conjugation, utilization of tumor specific promoters and viral mutation in order to take advantage of proteins overexpressed in tumor cells. This review analyzes these techniques applied to liposomal, PEI, dendrimer, stem cell and viral gene delivery systems in order to determine the techniques that are most effective in achieving tumor specific gene expression after systemic administration.
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影响因子：
5.1
作者：
Kircheis, R;Wightman, L;Wagner, E
通讯作者：
Wagner, E
影响因子：
10.8
作者：
Kanaoka, E;Takahashi, K;Hirano, K
通讯作者：
Hirano, K
DOI：
10.1093/jnci/91.20.1744
发表时间：
1999-10-20
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Gnant, MFX;Noll, LA;Bartlett, DL
通讯作者：
Bartlett, DL
影响因子：
5.8
作者：
Gomes-da-Silva, Ligia C.;Santos, Adriana O.;Moreira, Joao N.
通讯作者：
Moreira, Joao N.
影响因子：
4.7
作者：
Kursa, M;Walker, GF;Wagner, E
通讯作者：
Wagner, E