Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests.
Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests.
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DOI：
10.3389/neuro.08.003.2009
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发表时间：
2009
影响因子：
3
通讯作者：
Miyakawa T
中科院分区：
文献类型：
--
作者：
Matsuo N;Tanda K;Nakanishi K;Yamasaki N;Toyama K;Takao K;Takeshima H;Miyakawa T
细胞内Ca 2+浓度的动态调节对于各种神经元功能如突触传递和可塑性以及基因表达至关重要。Ryanodine受体（RyRs）是介导钙诱导的内质网钙释放的细胞内钙释放通道家族。在三种RyR亚型中，RyR 3优先在脑中表达，特别是在海马和纹状体中。为了研究RyR 3缺陷的行为影响，我们对RyR 3敲除（RyR 3-/-）小鼠进行了一系列行为测试。RyR 3-/-小鼠在两种不同的社会互动测试中表现出显著减少的社会接触时间，其中两只小鼠可以自由移动并相互接触。他们还表现出多动症和轻度受损的前脉冲抑制和潜伏抑制，而他们没有表现出显着异常的运动功能和工作和参考记忆测试。这些结果表明RyR 3在运动活动和社会行为中具有重要作用。
Dynamic regulation of the intracellular Ca2+ concentration is crucial for various neuronal functions such as synaptic transmission and plasticity, and gene expression. Ryanodine receptors (RyRs) are a family of intracellular calcium release channels that mediate calcium-induced calcium release from the endoplasmic reticulum. Among the three RyR isoforms, RyR3 is preferentially expressed in the brain especially in the hippocampus and striatum. To investigate the behavioral effects of RyR3 deficiency, we subjected RyR3 knockout (RyR3–/–) mice to a battery of behavioral tests. RyR3–/– mice exhibited significantly decreased social contact duration in two different social interaction tests, where two mice can freely move and make contacts with each other. They also exhibited hyperactivity and mildly impaired prepulse inhibition and latent inhibition while they did not show significant abnormalities in motor function and working and reference memory tests. These results indicate that RyR3 has an important role in locomotor activity and social behavior.
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影响因子：
11.4
作者：
Bertocchini, F;Ovitt, CE;Sorrentino, V
通讯作者：
Sorrentino, V
DOI：
10.1083/jcb.128.5.893
发表时间：
1995-03
期刊：
The Journal of cell biology
影响因子：
--
作者：
Giannini G;Conti A;Mammarella S;Scrobogna M;Sorrentino V
通讯作者：
Sorrentino V
影响因子：
64.8
作者：
Arron, Joseph R.;Winslow, Monte M.;Crabtree, Gerald R.
通讯作者：
Crabtree, Gerald R.
影响因子：
64.5
作者：
BRILLANTES, AMB;ONDRIAS, K;MARKS, AR
通讯作者：
MARKS, AR
DOI：
10.1073/pnas.1432927100
发表时间：
2003-07-22
影响因子：
11.1
作者：
Gerber, DJ;Hall, D;Tonegawa, S
通讯作者：
Tonegawa, S