Supplementation with Tetrahydrocurcumin Enhances the Therapeutic Effects of Dexamethasone in a Murine Model of Allergic Asthma
Supplementation with Tetrahydrocurcumin Enhances the Therapeutic Effects of Dexamethasone in a Murine Model of Allergic Asthma
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补充四氢姜黄素可增强地塞米松在过敏性哮喘小鼠模型中的治疗效果
DOI：
10.1159/000509367
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发表时间：
2020-08
影响因子：
2.8
通讯作者：
Yan Yang
中科院分区：
文献类型：
--
作者：
Yin Fan Wu;Yan Qiu Chen;Qin Li;Xiao Yan Ye;Xiao Zuo;Yi Lin Shi;Xing Yue Guo;Lin Xu;Lin Sun;Chun-Wei Li;Yan Yang
背景：/i/b四氢姜黄素（Tetrahydrocurcumin， THC）是姜黄素的主要活性代谢产物，姜黄素是一种来源于iCurcuma/i物种的膳食因子。我们之前的研究表明四氢大麻酚对过敏性哮喘小鼠有显著的有益作用。糖皮质激素（GCs）是治疗哮喘的常用药物。补充四氢大麻酚是否能促进GC治疗哮喘的有益效果尚未见报道。本研究旨在探讨GC和四氢大麻酚联合治疗过敏性哮喘小鼠模型的疗效。方法：将BALB/c小鼠随机分为5组：对照组、卵清蛋白（OVA）诱导组、OVA诱导小鼠分别饲喂四氢呋嗪、腹腔注射地塞米松（DEX）、四氢呋嗪联合DEX治疗。评估鼻部症状、肺组织的组织病理学改变、肺细胞因子的产生和Th细胞亚群。结果：四氢大麻酚（THC）或去氧咪唑（DEX）对鼻部症状和病理性肺改变均有有益影响，四氢大麻酚（THC）与去氧咪唑（DEX）治疗效果相当。重要的是，与单药组（仅使用四氢大麻酚或去氧咪唑）相比，四氢大麻酚和去氧咪唑联合使用可以显著减少摩擦鼻腔的频率，降低粘液分泌，降低Th2和Th17细胞数量以及降低相关细胞因子水平（IL-4、IL-5和IL-17A）。结论：/i/b补充四氢大麻酚可增强DEX的治疗效果，减轻气道症状、肺部炎症和Th2反应。我们的研究结果表明，四氢大麻酚的饮食管理可以作为一个附加治疗的哮喘与gc治疗。
biBackground:/i/b Tetrahydrocurcumin (THC) is the major active metabolite of curcumin, which is a dietary factor derived from iCurcuma/i species. Our previous study demonstrated a significant beneficial effect of THC in mice with allergic asthma. Glucocorticosteroids (GCs) are commonly used drugs in asthma. Whether THC supplementation could promote the beneficial effects of GC therapy on asthma has not yet been reported. The current study aimed to investigate the combined efficacy of GC and THC treatment in a mouse model of allergic asthma. biMethods:/i/b BALB/c mice were randomly divided into 5 groups: the control group, ovalbumin (OVA)-induced group, and OVA-induced mice treated with dietary THC only, intraperitoneal injection of dexamethasone (DEX) only, or THC combined with DEX. The nasal symptoms, histopathological alterations of lung tissues, lung cytokine production, and Th cell subsets were assessed. biResults:/i/b THC or DEX had beneficial effects on nasal symptoms and pathological lung changes, and the therapeutic effects between THC and DEX treatment were comparable. Importantly, compared to the monotherapy groups (THC or DEX only), the combination of THC and DEX showed a significantly reduced nasal rubbing frequency, lower mucus hyperproduction, lower Th2 and Th17 cell numbers as well as lower related cytokine levels (IL-4, IL-5, and IL-17A). biConclusions:/i/b Supplementation with THC can enhance the therapeutic effects of DEX to alleviate airway symptoms, lung inflammation, and the Th2 response. Our findings suggest that dietary administration of THC could act as an add-on therapy for asthma treated with GCs.
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影响因子：
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作者：
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通讯作者：
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