Emerging nanomedicines for effective breast cancer immunotherapy.
Emerging nanomedicines for effective breast cancer immunotherapy.
复制标题
新兴的纳米药物用于有效的乳腺癌免疫治疗。
DOI：
10.1186/s12951-020-00741-z
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发表时间：
2020-12-09
影响因子：
10.2
通讯作者：
Luo H
中科院分区：
文献类型：
--
作者：
Bahreyni A;Mohamud Y;Luo H
乳腺癌仍然是妇女中最常见的恶性肿瘤，危及她们的生命。癌症免疫治疗是一种新的方法，能够增强宿主免疫系统以高选择性识别和根除癌细胞。作为一种有前途的治疗方法，免疫治疗不仅可以消除原发肿瘤，而且被证明可以有效地阻止转移和复发。然而，癌症免疫治疗的临床应用面临着一些限制，包括由于免疫刺激剂向免疫细胞的递送不足以及免疫系统的不受控制的调节而产生弱的免疫应答，这可引起自身免疫和非特异性炎症。越来越多的证据表明，纳米技术可以满足当前癌症免疫治疗的需求。先进的生物材料，如纳米颗粒，提供了一个独特的机会，以最大限度地提高免疫治疗的效率，并显着减少其毒副作用。在这里，我们讨论了最近的进展，已经在纳米粒子涉及乳腺癌免疫治疗，从直接激活免疫系统，通过肿瘤抗原和佐剂的免疫细胞，以改变肿瘤环境的免疫抑制和其他常规疗法的组合。
Breast cancer continues to be the most frequently diagnosed malignancy among women, putting their life in jeopardy. Cancer immunotherapy is a novel approach with the ability to boost the host immune system to recognize and eradicate cancer cells with high selectivity. As a promising treatment, immunotherapy can not only eliminate the primary tumors, but also be proven to be effective in impeding metastasis and recurrence. However, the clinical application of cancer immunotherapy has faced some limitations including generating weak immune responses due to inadequate delivery of immunostimulants to the immune cells as well as uncontrolled modulation of immune system, which can give rise to autoimmunity and nonspecific inflammation. Growing evidence has suggested that nanotechnology may meet the needs of current cancer immunotherapy. Advanced biomaterials such as nanoparticles afford a unique opportunity to maximize the efficiency of immunotherapy and significantly diminish their toxic side-effects. Here we discuss recent advancements that have been made in nanoparticle-involving breast cancer immunotherapy, varying from direct activation of immune systems through the delivery of tumor antigens and adjuvants to immune cells to altering immunosuppression of tumor environment and combination with other conventional therapies.
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影响因子：
30.5
作者：
通讯作者：
--
二元协同前药纳米颗粒通过协同调节免疫肿瘤微环境改善免疫治疗
影响因子：
29.4
作者：
Feng, Bing;Zhou, Fangyuan;Li, Yaping
通讯作者：
Li, Yaping
影响因子：
2.6
作者：
Alberto Salazar-Gonzalez, Jorge;Antonio Ruiz-Cruz, Alail;Moreno-Fierros, Leticia
通讯作者：
Moreno-Fierros, Leticia
DOI：
10.1007/s10552-018-1072-6
发表时间：
2018-10
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Al-Ajmi K;Lophatananon A;Yuille M;Ollier W;Muir KR
通讯作者：
Muir KR
影响因子：
4.4
作者：
Arab, Atefeh;Nicastro, Jessica;Behravan, Javad
通讯作者：
Behravan, Javad