Innate and adaptive immune cells in the tumor microenvironment.
Innate and adaptive immune cells in the tumor microenvironment.
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作者：
大多数肿瘤细胞表达的抗原可以介导宿主CD8+T细胞的识别。临床发现的癌症必须躲避了抗肿瘤免疫反应，才能逐渐生长。最近的研究根据肿瘤微环境的细胞和分子特征提出了两大类肿瘤逃逸。其中一个主要亚型显示T细胞炎症表型，包括浸润性T细胞、广泛的趋化因子谱和I型干扰素签名，表明天然免疫激活。这些肿瘤似乎通过免疫系统抑制通路的显性抑制效应来抵抗免疫攻击。另一种主要表型缺乏这种T细胞炎症表型，似乎通过免疫系统排斥或忽视来抵抗免疫攻击。这两种主要的肿瘤微环境表型可能需要不同的免疫治疗干预才能达到最大的治疗效果。
Most tumor cells express antigens that can mediate recognition by host CD8+ T cells. Cancers that are detected clinically must have evaded antitumor immune responses to grow progressively. Recent work has suggested two broad categories of tumor escape based on cellular and molecular characteristics of the tumor microenvironment. One major subset shows a T cell–inflamed phenotype consisting of infiltrating T cells, a broad chemokine profile and a type I interferon signature indicative of innate immune activation. These tumors appear to resist immune attack through the dominant inhibitory effects of immune system–suppressive pathways. The other major phenotype lacks this T cell–inflamed phenotype and appears to resist immune attack through immune system exclusion or ignorance. These two major phenotypes of tumor microenvironment may require distinct immunotherapeutic interventions for maximal therapeutic effect.
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影响因子：
11.2
作者：
Burnette BC;Liang H;Lee Y;Chlewicki L;Khodarev NN;Weichselbaum RR;Fu YX;Auh SL
通讯作者：
Auh SL
影响因子：
7.2
作者：
Bos R;Marquardt KL;Cheung J;Sherman LA
通讯作者：
Sherman LA
影响因子：
56.9
作者：
BOUSSIOTIS, VA;BARBER, DL;NADLER, LM
通讯作者：
NADLER, LM
影响因子：
64.5
作者：
CHEN, LP;ASHE, S;LINSLEY, PS
通讯作者：
LINSLEY, PS
影响因子：
45.3
作者：
Azimi, Farhad;Scolyer, Richard A.;Thompson, John F.
通讯作者：
Thompson, John F.