Prognostic significance of miR-1268a expression and its beneficial effects for post-operative adjuvant transarterial chemoembolization in hepatocellular carcinoma.
Prognostic significance of miR-1268a expression and its beneficial effects for post-operative adjuvant transarterial chemoembolization in hepatocellular carcinoma.
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miR-1268a表达的预后意义及其对肝细胞癌术后辅助经动脉化疗栓塞的有益作用
DOI：
10.1038/srep36104
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发表时间：
2016-10-31
影响因子：
4.6
通讯作者：
Long XD
中科院分区：
文献类型：
--
作者：
Lu YL;Yao JG;Huang XY;Wang C;Wu XM;Xia Q;Long XD
我们最近的研究表明，microRNA-1268a的变量可能参与肝细胞癌（HCC）的肿瘤发生。在此，我们试图通过对411例HCC患者的回顾性分析来确定肿瘤组织中microRNA-1268a表达的预后意义，并分析其对术后辅助经动脉化疗栓塞（TACE）改善HCC预后的影响。所有病例均接受肿瘤切除或肿瘤切除加术后辅助TACE作为初始治疗。 Logistic回归分析显示，microRNA-1268a表达与肿瘤分期、肿瘤分级、肿瘤大小和微血管密度显着相关。 Cox回归分析显示，microRNA-1268a表达是HCC的独立预后因素，TACE治疗对microRNA-1268a高表达的HCC患者的预后无影响。更有趣的是，TACE 改善了 microRNA-1268a 低表达的 HCC 患者的预后。从功能上讲，microRNA-1268a 的过度表达会抑制癌细胞的死亡，而其抑制剂则会增强阿霉素诱导的癌细胞死亡。这些结果表明microRNA-1268a可能是HCC患者的独立预后因素，并且降低microRNA-1268a表达可能有利于HCC术后辅助TACE治疗。
Our recent investigation has shown that the variables of microRNA-1268a may involve in hepatocellular carcinoma (HCC) tumorigenesis. Here, we attempted to identify the prognostic significance of microRNA-1268a expression in tumor tissues by a retrospective analysis in 411 patients with HCC, and analyze its effects on post-operative adjuvant transarterial chemoembolization (TACE) improving HCC prognosis. All cases received tumor resection or tumor resection plus post-operative adjuvant TACE as an initial treatment. Logistical regression analysis exhibited that microRNA-1268a expression was significantly correlated with tumor stage, tumor grade, tumor size, and microvessel density. Cox regression analysis showed that microRNA-1268a expression was an independent prognostic factor for HCC, and TACE treatment had no effects on prognosis of HCC patients with high microRNA-1268a expression. More intriguingly, TACE improved the prognosis of HCC patients with low microRNA-1268a expression. Functionally, overexpression of microRNA-1268a inhibited while its inhibitor enhanced doxorubicin-induced the death of cancer cells. These results suggest that microRNA-1268a may be an independent prognostic factor for HCC patients, and that decreasing microRNA-1268a expression may be beneficial for post-operative adjuvant TACE treatment in HCC.
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影响因子：
5.3
作者：
Wojcicka, A.;de la Chapelle, A.;Jazdzewski, K.
通讯作者：
Jazdzewski, K.
影响因子：
5.6
作者：
Ma X;Li RS;Wang J;Huang YQ;Li PY;Wang J;Su HB;Wang RL;Zhang YM;Liu HH;Zhang CE;Ma ZJ;Wang JB;Zhao YL;Xiao XH
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Xiao XH
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作者：
Morin, Ryan D.;O'Connor, Michael D.;Marra, Marco A.
通讯作者：
Marra, Marco A.
影响因子：
3.8
作者：
Huang, Xiao-Ying;Yao, Jin-Guang;Long, Xi-Dai
通讯作者：
Long, Xi-Dai
影响因子：
14.9
作者：
Griffiths-Jones S;Grocock RJ;van Dongen S;Bateman A;Enright AJ
通讯作者：
Enright AJ