Evaluation of the relationship between polymorphisms in CYP2C19 and the single-dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study.
Evaluation of the relationship between polymorphisms in CYP2C19 and the single-dose pharmacokinetics of omeprazole in healthy Chinese volunteers: A multicenter study.
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中国健康志愿者CYP2C19多态性与奥美拉唑单剂量药代动力学关系评价：一项多中心研究
DOI：
10.1111/cts.13255
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发表时间：
2022-06
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
The aim of this study was to evaluate the relationship between polymorphisms in CYP2C19 and the single‐dose pharmacokinetics (PKs) of omeprazole in healthy Chinese volunteers. A 20 mg single dose of omeprazole (Losec) enteric‐coated capsules or tablets was orally administered to 656 healthy subjects from eight subcenters. The polymorphic alleles of CYP2C19*2, *3, and *17 were determined by Sanger sequencing and Agena mass array. Plasma concentrations of omeprazole were determined by high‐performance liquid‐chromatography tandem mass spectrometry. PK parameters of area under the concentration versus time curve (AUC)0‐t, AUC from zero to infinity (AUC0‐∞), maximum plasma concentration (Cmax), and terminal half‐life (t1/2) were significantly influenced by CYP2C19 phenotype (all p < 0.001) and diplotype (all p < 0.001), and the same results were obtained in the subgroup analysis of the effects of diet and dosage form. The polymorphisms of CYP2C19*2(rs4244285; all PK parameters p < 0.001) and *3(rs4986893; p Cmax = 0.020, and the p values of other PK parameters were less than 0.001) were significantly associated with the PKs of omeprazole. For CYP2C19*17 (rs12248560), only t1/2 showed a significant correlation (p = 0.032), whereas other PK parameters did not. The present study demonstrated that the Pks of omeprazole is greatly influenced by CYP2C19.
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影响因子：
4.5
作者：
Park S;Hyun YJ;Kim YR;Lee JH;Ryu S;Kim JM;Oh WY;Na HS;Lee JG;Seo DW;Hwang IY;Park Z;Jang IJ;Oh J;Choi SE
通讯作者：
Choi SE
影响因子：
2.9
作者：
Yin, OQR;Tomlinson, B;Chow, MSS
通讯作者：
Chow, MSS
影响因子：
6.7
作者：
Lima JJ;Thomas CD;Barbarino J;Desta Z;Van Driest SL;El Rouby N;Johnson JA;Cavallari LH;Shakhnovich V;Thacker DL;Scott SA;Schwab M;Uppugunduri CRS;Formea CM;Franciosi JP;Sangkuhl K;Gaedigk A;Klein TE;Gammal RS;Furuta T
通讯作者：
Furuta T
DOI：
10.1038/tpj.2013.17
发表时间：
2014-04
期刊：
The pharmacogenomics journal
影响因子：
--
作者：
Michaud V;Kreutz Y;Skaar T;Ogburn E;Thong N;Flockhart DA;Desta Z
通讯作者：
Desta Z
影响因子：
3.4
作者：
Hunfeld, Nicole G.;Mathot, Ron A.;Geus, William P.
通讯作者：
Geus, William P.