LONGITUDINAL STUDY OF PERSISTENT GENERALISED LYMPHADENOPATHY IN HOMOSEXUAL MEN: RELATION TO ACQUIRED IMMUNODEFICIENCY SYNDROME
LONGITUDINAL STUDY OF PERSISTENT GENERALISED LYMPHADENOPATHY IN HOMOSEXUAL MEN: RELATION TO ACQUIRED IMMUNODEFICIENCY SYNDROME
复制标题
男同性恋持续性全身淋巴结病的纵向研究：与获得性免疫缺陷综合征的关系
DOI：
10.1016/s0140-6736(84)91449-1
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
D. Mildvan
中科院分区：
文献类型：
--
作者：
U. Mathur;I. Spigland;H. Sacks;S. Yancovitz;D. William;R. Enlow;R. Winchester;E. Rorat;M. Klein;D. Mildvan
自1981年2月以来，对42名同性恋或双性恋男性患者进行了纵向随访，这些患者患有无法确定原因的持续性全身淋巴结病。淋巴结病伴有疲乏、低热和/或盗汗（57%）、脾肿大（29%）、白细胞减少（40%）、高γ球蛋白血症（76%）和辅助性T细胞比例和绝对数量减少（95%）。26例淋巴结活检均为良性反应性增生。15-30个月（中位数22个月）后，8名患者符合获得性免疫缺陷综合征（AIDS）的诊断标准。这一结果与既往大量使用亚硝酸盐吸入剂、夜间盗汗、白细胞减少症以及全身症状、脾肿大和白细胞减少症三联征有关。此外，较低的平均绝对辅助T细胞计数和增加的频率无反应性腮腺炎皮内抗原和单纯疱疹病毒分离区分这些患者从那些留在队列中，谁似乎是稳定的，在某些情况下，已改善。
42 homosexual or bisexual men with persistent generalised lymphadenopathy not attributable to an identifiable cause have been followed longitudinally since February, 1981. Lymphadenopathy was accompanied by fatigue, low-grade fever and/or night sweats (57%), splenomegaly (29%), leucopenia (40%), hypergamma-globulinaemia (76%), and diminished proportion and absolute numbers of helper T cells (95%). Of the 26 patients who had lymph node biopsy, all showed benign reactive hyperplasia. After 15-30 (median 22) months, 8 patients have met criteria for the diagnosis of acquired immunodeficiency syndrome (AIDS). This outcome was associated with previous heavy nitrite inhalant use, with the presence of night sweats, with leucopenia, and with the triad of constitutional symptoms, splenomegaly, and leucopenia. In addition, a lower mean absolute helper T cell count and an increased frequency of anergy to mumps intradermal antigen and of herpes simplex virus isolation distinguished these patients from those remaining in the cohort, who seem to be stable and in some cases to have improved.
影响因子：
39.2
作者：
MORRIS, L;DISTENFELD, A;KARPATKIN, S
通讯作者：
KARPATKIN, S
DOI：
10.1016/0002-9343(82)90174-7
发表时间：
1982
期刊：
The American journal of medicine
影响因子：
--
作者：
Stahl,RE;Friedman-Kien,A;Dubin,R;Marmor,M;Zolla-Pazner,S
通讯作者：
Zolla-Pazner,S