Androgen Treatment Effects on Motor Function, Cognition, and Behavior in Boys with Klinefelter Syndrome.
Androgen Treatment Effects on Motor Function, Cognition, and Behavior in Boys with Klinefelter Syndrome.
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DOI：
10.1016/j.jpeds.2017.02.036
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Roeltgen D
中科院分区：
文献类型：
--
作者：
Ross JL;Kushner H;Kowal K;Bardsley M;Davis S;Reiss AL;Tartaglia N;Roeltgen D
To examine the effects of early low-dose androgen on motor, cognitive, and behavioral function in prepubertal boys with Klinefelter syndrome (47,XXY). Double-blind trial of 84 boys, ages 4–12 years, randomized to oxandrolone (Ox, 0.06 mg/kg daily, N=43) or placebo (Pl, N=41) for 24 months. Standardized assessments were performed at baseline and every 12 months for 24 months evaluating motor, cognitive, and behavioral function. The 24 month outcomes were better in the Ox vs. Pl group on one of five primary endpoints (motor function/strength): Bruininks Visual-Motor scale (P=0.005), without significant differences between the 2 groups for the other 4 components. Secondary analyses suggested improvement in the Ox vs. Pl group in the Anxiety/Depression (P=0.03) and Social Problems (P=0.01) scales on the Child Behavior Checklist, Anxiety (P=0.04) on the Piers Harris Self Concept Scale, and Interpersonal Problems (P=0.02) on the Children’s Depression Inventory, without significant differences in hyperactive or aggressive behaviors. This double-blind, randomized trial demonstrates that 24 months of childhood low-dose androgen treatment in boys with KS benefited one of five primary endpoints (visual-motor function). Secondary analyses demonstrated positive effects of androgen on aspects of psychosocial function (anxiety, depression, social problems), without significant effects on cognitive function, hyperactive or aggressive behaviors. ClinicalTrials.gov:
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影响因子：
4.5
作者：
Davis S;Lahlou N;Bardsley M;Temple MC;Kowal K;Pyle L;Zeitler P;Ross J
通讯作者：
Ross J
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