Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL.
Wnt/β-Catenin Protects Lymphocytes from HIV-Mediated Apoptosis via Induction of Bcl-xL.
复制标题
DOI：
10.3390/v14071469
复制
发表时间：
2022-07-02
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
HIV infection mediates the apoptosis of lymphocytes, the mechanism of which is multifaceted. Here, we evaluated the role of Wnt/β-catenin signaling in HIV-associated T cell apoptosis, as Wnt/β-catenin regulates the transcriptional activity of genes impacting apoptosis. We specifically investigated the role of the Wnt/β-catenin pathway in the HIV-associated apoptosis of CD4+ T cells and CD4dimCD8bright T cells, a population that is infected by HIV. We found that the induction of β-catenin, via a 6-bromoindirubin-3-oxime (BIO), significantly rescued HIV-infected CD4+ and CD4dimCD8bright T cells from apoptosis by >40–50%. Further, a small-molecule inhibitor of the Wnt/β-catenin pathway (PNU-74654) reversed BIO-mediated protection from HIV-associated apoptosis. BIO also induced Bcl-xL, an anti-apoptotic protein, and a target gene of Wnt/β-catenin, in CD4+ and CD4dimCD8bright T cells by approximately 3-fold. Inhibiting Bcl-xL by WEHI-539 abrogated β-catenin-mediated apoptotic protection in infected CD4+ and CD4dimCD8bright T cells. Collectively, these findings demonstrate that engaging Wnt/β-catenin signaling in HIV-infected T cells protects them from HIV-associated apoptosis by inducing Bcl-xL.
登录
查看更多内容
DOI：
10.1084/jem.187.7.1113
发表时间：
1998-04-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Gandhi RT;Chen BK;Straus SE;Dale JK;Lenardo MJ;Baltimore D
通讯作者：
Baltimore D
影响因子：
5.4
作者：
Jekle, A;Kepler, OT;Goldsmith, MA
通讯作者：
Goldsmith, MA
DOI：
10.1073/pnas.92.11.4763
发表时间：
1995-05-23
影响因子：
11.1
作者：
MA, A;PENA, JC;THOMPSON, CB
通讯作者：
THOMPSON, CB
DOI：
10.1186/1478-811x-12-29
发表时间：
2014-04-26
期刊：
Cell communication and signaling : CCS
影响因子：
--
作者：
Hillesheim A;Nordhoff C;Boergeling Y;Ludwig S;Wixler V
通讯作者：
Wixler V
影响因子：
6.7
作者：
Barbian HJ;Seaton MS;Narasipura SD;Wallace J;Rajan R;Sha BE;Al-Harthi L
通讯作者：
Al-Harthi L