Corticotropin (ACTH)-reactive immunoglobulins in adolescents in relation to antisocial behavior and stress-induced cortisol response. The TRAILS study
Corticotropin (ACTH)-reactive immunoglobulins in adolescents in relation to antisocial behavior and stress-induced cortisol response. The TRAILS study
复制标题
青少年中促肾上腺皮质激素（ACTH）反应性免疫球蛋白与反社会行为和压力诱导的皮质醇反应有关。
DOI：
10.1016/j.psyneuen.2013.08.015
复制
发表时间：
2013
影响因子：
3.7
通讯作者：
F. Oort
中科院分区：
文献类型：
--
作者：
Johanna M. Schaefer;S. Fetissov;R. Legrand;S. Claeyssens;P. Hoekstra;F. Verhulst;F. Oort
在行为障碍男性中发现促肾上腺皮质激素（ACTH）反应性免疫球蛋白（ACTH IgG）水平升高，提示其参与反社会行为的生物学过程。我们首先试图在一个大的一般青少年人群样本中证实这些发现。其次，我们研究了ACTH IgG水平与下丘脑-垂体-肾上腺（HPA）轴对应激反应的关系。测定1230例15 ~ 18岁青少年血清游离和总ACTH IgG水平。在社会压力测试之前、期间和之后，通过测量唾液皮质醇来确定HPA轴的活性。反社会行为采用反社会行为问卷进行评估。在选择高或低ACTH IgG水平的90名青少年亚样本中，测定了ACTH肽和IgG对ACTH的亲和动力学。在男孩中，较高的总ACTH IgG水平与较高的反社会行为评分相关（β= 1.05,p= 0.04），特别是在高水平的游离ACTH IgG时。在女孩中，反社会行为与低游离ACTH IgG水平相关（β= - 0.20,p= 0.04）。应激诱导的皮质醇释放与男孩（β曲线下面积= - 0.67,p< 0.01）和女孩（β恢复= 0.84,p= 0.05）游离ACTH IgG相关。亲和动力学分析显示，ACTH IgG高水平的男孩和女孩的ACTH IgG关联率较低。这些数据表明，ACTH IgG水平与青少年反社会行为和HPA轴应激反应有关。这些关联背后的机制，包括IgG在反社会行为受试者中不同的ACTH结合特性，值得进一步关注。
Elevated levels of corticotropin (ACTH)-reactive immunoglobulins (ACTH IgG) were found in males with conduct disorder, suggesting their involvement in the biology of antisocial behavior. We first aimed to confirm these findings in a large general population sample of adolescents. Secondly, we studied the association between ACTH IgG levels and hypothalamic–pituitary–adrenal (HPA) axis response to stress.Free and total ACTH IgG levels were measured in sera of 1230 adolescents (15–18 years). HPA axis activity was determined by measuring salivary cortisol before, during, and after a social stress test. Antisocial behavior was assessed using the Antisocial Behavior Questionnaire. ACTH peptide and IgG affinity kinetics for ACTH were assayed in a subsample of 90 adolescents selected for high or low ACTH IgG levels.In boys, higher total ACTH IgG levels were associated with higher antisocial behavior scores (β= 1.05,p= 0.04), especially at high levels of free ACTH IgG. In girls, antisocial behavior was associated with low free ACTH IgG levels (β= −0.20,p= 0.04). Stress-induced cortisol release was associated with free ACTH IgG in boys (βarea under the curve= −0.67,p< 0.01), and with total ACTH IgG in girls (βrecovery= 0.84,p= 0.05). The affinity kinetics assay showed that ACTH IgG association rates were lower in both boys and girls with high ACTH IgG levels.These data show that ACTH IgG levels are related to antisocial behavior and HPA axis response to stress in adolescents. The mechanisms behind these associations, including different ACTH binding properties of IgG in subjects with antisocial behavior, deserve further attention.
青春期男孩的唾液皮质醇、性格和攻击行为：一项为期 5 年的纵向研究。
DOI：
10.1097/01.chi.0000070246.24125.6d
发表时间：
2003
期刊：
Journal of the American Academy of Child and Adolescent Psychiatry.
影响因子：
--
作者：
Shoal,GavinD;Giancola,PeterR;Kirillova,GalinaP
通讯作者：
Kirillova,GalinaP
未经选择的出生队列中的神经心理缺陷和自我报告的犯罪行为。
DOI：
10.1097/00004583-198803000-00017
发表时间：
1988
影响因子：
13.3
作者：
Moffitt,TE;Silva,PA
通讯作者：
Silva,PA
影响因子：
4.6
作者：
Kim, KJ;Conger, RD;Lorenz, FO
通讯作者：
Lorenz, FO