High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma.
High expression of MAGE-A9 correlates with unfavorable survival in hepatocellular carcinoma.
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DOI：
10.1038/srep06625
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发表时间：
2014-10-15
影响因子：
4.6
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Gu X;Fu M;Ge Z;Zhan F;Ding Y;Ni H;Zhang W;Zhu Y;Tang X;Xiong L;Li J;Qiu L;Mao Y;Zhu J
据报道，黑色素瘤相关抗原 (MAGE)-A9 在人类癌症的发展中发挥重要作用。然而，MAGE-A9 表达与肝细胞癌 (HCC) 临床病理特征之间的关联尚不清楚。本研究旨在检测MAGE-A9在人HCC中的表达，并探讨其表达与HCC临床病理特征的关系。采用逆转录聚合酶链反应 (RT-PCR)、一步定量 PCR (qPCR) 和免疫组织化学 (IHC) 分析来表征 HCC 细胞系和组织中 MAGE-A9 的表达。采用 Kaplan-Meier 生存和 Cox 回归分析来评估 100 名 HCC 患者的预后。结果显示，HCC中MAGE-A9的表达显着高于非癌细胞和组织。此外，HCC中MAGE-A9蛋白的表达水平与病理分级（p = 0.003）、门静脉侵犯（p = 0.001）、远处转移（p = 0.022）和TNM分期（p = 0.005）相关。 Cox回归分析进一步显示，MAGE-A9表达是无病生存（p = 0.006）和总生存（p = 0.022）的独立预后因素。这些数据首次表明 MAGE-A9 表达是 HCC 的一个有价值的预后生物标志物，并且高 MAGE-A9 表达表明 HCC 患者的生存结果不佳。
Melanoma-associated antigens (MAGE)-A9 has been reported to play important roles in the development of human cancers. However, the association between MAGE-A9 expression and the clinicopathological characteristics of hepatocellular carcinoma (HCC) is not well understood. The study was to detect the expression of MAGE-A9 in human HCC and investigate the association between its expression and the clinicopathological characteristics of HCC. Reverse transcription-polymerase chain reaction (RT-PCR), one-step quantitative -PCR (qPCR) and immunohistochemistry (IHC) analyses were performed to characterize the expression of MAGE-A9 in HCC cell lines and tissues. Kaplan-Meier survival and Cox regression analyses were employed to evaluate the prognosis of 100 HCC patients. The results showed that the expression of MAGE-A9 in HCC was significantly higher than that in non-cancerous cells and tissues. Moreover, the expression level of the MAGE-A9 protein in HCC was related to the pathological grade (p = 0.003), portal vein invasion (p = 0.001), distant metastasis (p = 0.022) and TNM stage (p = 0.005). Cox regression analysis further revealed that MAGE-A9 expression is an independent prognostic factor for disease-free survival (p = 0.006) and overall survival (p = 0.022). These data are the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for HCC and that high MAGE-A9 expression suggests unfavorable survival outcomes in HCC patients.
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DOI：
10.1158/1078-0432.ccr-10-1820
发表时间：
2011-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Nardiello T;Jungbluth AA;Mei A;Diliberto M;Huang X;Dabrowski A;Andrade VC;Wasserstrum R;Ely S;Niesvizky R;Pearse R;Coleman M;Jayabalan DS;Bhardwaj N;Old LJ;Chen-Kiang S;Cho HJ
通讯作者：
Cho HJ
影响因子：
--
作者：
Straetemans T;van Brakel M;van Steenbergen S;Broertjes M;Drexhage J;Hegmans J;Lambrecht BN;Lamers C;van Der Bruggen P;Coulie PG;Debets R
通讯作者：
Debets R
人抗 MAGE-A1 scFv 和免疫毒素的选择和表征。
影响因子：
2.8
作者：
Lin, Hong;Mao, Yuan;Chen, Ren-Jie
通讯作者：
Chen, Ren-Jie
影响因子：
6.4
作者：
Picard, Valerie;Bergeron, Alain;Fradet, Yves
通讯作者：
Fradet, Yves
干扰素-β基因改性的人骨骨髓间充质干细胞通过抑制AKT/FOXO3A途径减弱肝细胞癌。
影响因子：
8.8
作者：
Xie C;Xie DY;Lin BL;Zhang GL;Wang PP;Peng L;Gao ZL
通讯作者：
Gao ZL