High Expression of SQSTM1/p62 Protein Is Associated with Poor Prognosis in Epithelial Ovarian Cancer.
High Expression of SQSTM1/p62 Protein Is Associated with Poor Prognosis in Epithelial Ovarian Cancer.
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DOI：
10.1267/ahc.14048
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发表时间：
2014
影响因子：
2.4
通讯作者：
Inazawa J
中科院分区：
文献类型：
--
作者：
Iwadate R;Inoue J;Tsuda H;Takano M;Furuya K;Hirasawa A;Aoki D;Inazawa J
SQSTM1/p62 （p62）蛋白的高表达，作为各种细胞信号通路的枢纽，已在几种人类癌症中被检测到。然而，p62高表达在上皮性卵巢癌（EOC）中的临床病理影响在很大程度上是未知的。本研究采用免疫组化方法检测p62在原发EOCs （n=266）中的表达水平，并分析其临床意义。采用单因素和多因素分析确定p62表达对总生存期的影响。p62在原发性EOCs中表达于细胞质（Cyto）和/或细胞核（Nuc）中，其中细胞质高表达、细胞核低表达的表达亚型（CytoHigh/NucLow）与浆液性癌（P<0.001）、晚期（P=0.005）、残留肿瘤（P<0.001）和低总生存率（P=0.013）显著相关。此外，在浆液性癌（n=107）中，p62 CytoHigh/NucLow亚型作为一个独立因素与低总生存率显著相关（P=0.019） （P=0.044）。因此，我们的研究结果表明，细胞质p62的高表达可能是EOC，特别是浆液性癌的一种新的预后生物标志物。
High expression of SQSTM1/p62 (p62) protein, which functions as a hub for various cellular signaling pathways, has been detected in several human cancers. However, the clinicopathological impact of high p62 expression is largely unknown in epithelial ovarian cancer (EOC). Here, the expression level of p62 in primary EOCs (n=266) was assessed by immunohistochemistry, and its clinical significance was analyzed. Univariate and multivariate analyses were used to determine the impact of p62 expression on overall survival. p62 was expressed in the cytoplasm (Cyto) and/or nucleus (Nuc) in primary EOCs, and an expression subtype (CytoHigh/NucLow), showing high expression in the cytoplasm but low expression in the nucleus, was significantly correlated with serous carcinoma (P<0.001), advanced stage (P=0.005), presence of residual tumor (P<0.001), and low overall survival rate (P=0.013). Furthermore, in serous carcinomas (n=107), the p62 CytoHigh/NucLow subtype was significantly correlated with low overall survival rate (P=0.019) as an independent factor (P=0.044). Thus, our findings suggest that high expression of cytoplasmic p62 may be a novel prognostic biomarker in EOC, particularly in serous carcinoma.
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影响因子：
3.8
作者：
Kobayashi T;Masutomi K;Tamura K;Moriya T;Yamasaki T;Fujiwara Y;Takahashi S;Yamamoto J;Tsuda H
通讯作者：
Tsuda H
影响因子：
3.7
作者：
Inui T;Chano T;Takikita-Suzuki M;Nishikawa M;Yamamoto G;Okabe H
通讯作者：
Okabe H
影响因子：
4.8
作者：
Jain, Ashish;Lamark, Trond;Johansen, Terje
通讯作者：
Johansen, Terje
影响因子：
13.3
作者：
Sahani MH;Itakura E;Mizushima N
通讯作者：
Mizushima N
p62/SQSTM1形成自噬降解的蛋白质聚集体，并对亨廷顿蛋白诱导的细胞死亡具有保护作用。
影响因子：
7.8
作者：
Bjorkoy, Geir;Lamark, Trond;Brech, Andreas;Outzen, Heidi;Perander, Maria;Overvatn, Aud;Stenmark, Harald;Johansen, Terje
通讯作者：
Johansen, Terje