Nucleostemin expression in invasive breast cancer.
Nucleostemin expression in invasive breast cancer.
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DOI：
10.1186/1471-2407-14-215
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发表时间：
2014-03-21
期刊：
影响因子：
3.8
通讯作者：
Tsuda H
中科院分区：
文献类型：
--
作者：
Kobayashi T;Masutomi K;Tamura K;Moriya T;Yamasaki T;Fujiwara Y;Takahashi S;Yamamoto J;Tsuda H
最近，癌症干细胞假说已被广泛接受。癌症干细胞被认为具有自我更新和分化的能力，类似于正常干细胞。核干细胞蛋白（NS）最初从大鼠神经干细胞中克隆，与细胞核中的各种蛋白质（包括p53）结合，被认为是干细胞的关键分子。NS在各种类型的癌症中表达;因此，其在癌症发病机制中的作用被认为是重要的。本研究旨在阐明NS对浸润性乳腺癌的临床病理学和预后的影响。采用组织微阵列技术检测了220例连续手术切除的浸润性乳腺癌组织中NS免疫反应性与临床病理参数之间的相关性。在10%或更多的癌细胞中存在核NS和p53免疫反应性被认为是阳性结果。在220例患者中，154例为HER 2受体（HR）阳性，22例为HER 2阳性/HR阴性，44例为HR阴性/HER 2阴性。142例（64.5%）肿瘤显示NS阳性，并且该阳性与雌激素受体（ER）（P = 0.050）、人表皮生长因子受体2（HER 2）（P = 0.021）和p53（P = 0.031）阳性显著相关。NS阳性肿瘤患者的无病生存期明显短于NS阴性肿瘤患者。此外，NS和p53阳性肿瘤患者组的预后明显差于其他患者组。多因素分析显示NS状态是独立的预后指标。NS可能在确定与p53改变相关的乳腺癌进展中发挥重要作用。管腔型和HER 2型乳腺癌患者的NS状态可能是一个有用的预后指标。
Recently, the cancer stem cell hypothesis has become widely accepted. Cancer stem cells are thought to possess the ability to undergo self-renewal and differentiation, similar to normal stem cells. Nucleostemin (NS), initially cloned from rat neural stem cells, binds to various proteins, including p53, in the nucleus and is thought to be a key molecule for stemness. NS is expressed in various types of cancers; therefore, its role in cancer pathogenesis is thought to be important. This study was conducted to clarify the clinicopathological and prognostic impact of NS in invasive breast cancers. The correlation between NS immunoreactivity and clinicopathological parameters was examined in 220 consecutive surgically resected invasive breast cancer tissue samples by using tissue microarrays. The presence of nuclear NS and p53 immunoreactivity in 10% or more of cancer cells was considered as a positive result. Among the 220 patients, 154 were hormone-receptor (HR)-positive, 22 HER2-positive/HR-negative, and 44 HR-negative/HER2-negative. One hundred and forty-two tumors (64.5%) showed NS positivity, and this positivity was significantly correlated with estrogen receptor (ER) (P = 0.050), human epidermal growth factor receptor 2 (HER2) (P = 0.021), and p53 (P = 0.031) positivity. The patients with NS-positive tumors showed significantly shorter disease-free survival than those with NS-negative tumors. Furthermore, the patient group with NS- and p53-positive tumors showed significantly poorer prognosis than other patient groups. Multivariate analysis showed that NS status was an independent prognostic indicator. NS may play a significant role in the determination of breast cancer progression in association with p53 alterations. The NS status of patients with luminal and HER2 type breast cancers may be a useful prognostic marker.
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影响因子：
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影响因子：
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影响因子：
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