Effects of the Fusarium toxin zearalenone (ZEA) and/or deoxynivalenol (DON) on the serum IgA, IgG and IgM levels in mice
Effects of the Fusarium toxin zearalenone (ZEA) and/or deoxynivalenol (DON) on the serum IgA, IgG and IgM levels in mice
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镰刀菌毒素玉米赤霉烯酮 (ZEA) 和/或脱氧雪腐镰刀菌烯醇 (DON) 对小鼠血清 IgA、IgG 和 IgM 水平的影响
DOI：
10.1080/09540105.2013.867928
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发表时间：
2014
影响因子：
3
通讯作者：
J. Fang
中科院分区：
文献类型：
--
作者：
Z. Ren;R. Zhou;J. Deng;Z. Zuo;X. Peng;Y. Wang;Y. Wang;S. Yu;L. Shen;H. Cui;J. Fang
本研究的目的是评估镰刀菌毒素玉米赤霉烯酮 (ZEA) 和/或脱氧雪腐镰刀菌烯醇 (DON) 对小鼠血清 IgA、IgG 和 IgM 水平的影响。在我们的研究中，360 只健康成年雌性小鼠被随机分为 9 组，进行为期 12 天的研究。各组小鼠分别连续腹腔注射不同浓度的ZEA、DON以及ZEA和DON的混合物，为期4天。在实验的第0、3、5、8和12天收集血样。实验结果表明，各实验组均可引起免疫球蛋白失调，从而影响小鼠的体液免疫。混合组，尤其是ZEA和DON浓度较高的组(D2Z2组)，对免疫球蛋白失调的作用更为明显。
The aim of this study was to evaluate the effects of the Fusarium toxin zearalenone (ZEA) and/or deoxynivalenol (DON) on the serum IgA, IgG and IgM levels in mice. In our study, 360 healthy adult female mice were randomly assigned to nine groups for a 12-day study. Mice of all groups were given a 4-day continuous intraperitoneal injection with different concentrations of ZEA alone, DON alone and the mixture of ZEA and DON, individually. Blood samples were collected on days 0, 3, 5, 8 and 12 of the experiment. The experiment results showed that all the experimental groups could cause the dysregulation of the immunoglobulin, thus affecting the humoral immune of mice. The mixture groups, especially in the group with higher concentrations of ZEA and DON (Group D2Z2), showed more obvious effect on the dysregulation of the immunoglobulin.
影响因子：
3.5
作者：
Pestka, JJ;Zhou, HR;Chung, YJ
通讯作者：
Chung, YJ
影响因子：
4.3
作者：
Flannery, Brenna M.;Wu, Wenda;Pestka, James J.
通讯作者：
Pestka, James J.