Retinal phototoxicity from the operating microscope. The role of inspired oxygen.
Retinal phototoxicity from the operating microscope. The role of inspired oxygen.
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手术显微镜下的视网膜光毒性。
DOI：
10.1016/s0161-6420(88)33065-4
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发表时间：
1988
期刊：
影响因子：
13.7
通讯作者：
Haugen,C
中科院分区：
文献类型：
--
作者：
Jaffe,GJ;Irvine,AR;Wood,IS;Severinghaus,JW;Pino,GR;Haugen,C
用手术显微镜观察了吸入氧浓度（FI_（02））对有晶状体眼恒河猴视网膜光毒性产生的影响。每只猴的一只眼睛在99%FIO2条件下暴露于光，另一只眼睛在21%氧气（O2）下暴露。每个视网膜上的四个位置中的三个位置暴露于光，每次暴露持续时间从1 1/2到20分钟不等。在暴露后24至72小时获得眼底照片和荧光素血管造影照片。在光暴露后2周至8个月的时间间隔，对动物实施安乐死以分析视网膜组织病理学。视网膜光毒性病变产生后，平均5分钟的光暴露在21和99%O2。在临床和组织学上，O2都加强了光损伤。在这两种情况下，病变大小与光照时间直接相关（P< 0.005）。使用99%FIO2产生的阈值附近的病变比使用21%FIO2形成的相应病变大1.6至6.9（平均2.9）倍。在高氧条件下产生的病变组织学损伤同样更严重。视网膜修复发生在高和低O2条件下产生的病变。光感受器再生在18周时几乎完成，而视网膜色素上皮（RPE）的恢复滞后了11/2个月。这项研究的结果对临床实践具有重要意义：手术显微镜可以迅速产生视网膜光毒性，如果不采取适当的预防措施，眼科手术期间给予的O2可能会加剧损害。
The effect of the inspired oxygen concentration (FI02) on the production of retinal phototoxicity by the operating microscope was studied in phakic rhesus monkeys. One eye of each monkey was exposed to light under conditions of 99% FIO2, and the other eye was exposed under 21 % oxygen (O2)Three of four locations on each retina were exposed to light for durations varying from 1 1/2 to 20 minutes per exposure. Fundus photographs and fluorescein angiograms were obtained 24 to 72 hours after exposure. Animals were euthanatized for analysis of retinal histopathology at intervals from 2 weeks to 8 months after light exposure. Retinal phototoxic lesions were produced after an average of 5 minutes of light exposure under both 21 and 99% O2. O2potentiated the light damage both clinically and histologically. Under both conditions, lesion size was directly related to the duration of light exposure (P< 0.005). Lesions near threshold produced with 99% FIO2were 1.6 to 6.9 (mean, 2.9) times larger than the corresponding lesions formed with 21 % FIO2. Histologic damage was likewise more severe in lesions produced under high O2conditions. Retinal repair occurred in lesions produced under high and low O2conditions. Photoreceptor regeneration was nearly complete by 18 weeks, whereas retinal pigment epithelial (RPE) recovery lagged up to 11/2 months. The results of this study have important implications for clinical practice: the operating microscope can produce retinal phototoxicity rapidly, and O2administered during ophthalmic procedures may potentiate the damage if appropriate precautions are not taken.
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光在灵长类动物视网膜中引起的三个主要病理过程：寻找机制。
DOI：
--
发表时间：
1982
期刊：
Transactions of the American Ophthalmological Society
影响因子：
--
作者：
T. Lawwill
通讯作者：
T. Lawwill
光损伤对视网膜组织的影响。
影响因子：
13.7
作者：
Tso,MO;Woodford,BJ
通讯作者：
Woodford,BJ
DOI：
--
发表时间：
1968
期刊：
A M A Archives of Ophthalmology
影响因子：
--
作者：
T. Kuwabara;R. Gorn
通讯作者：
R. Gorn
与囊外白内障摘除术和后晶状体植入相关的光性视网膜损伤后黄斑功能的延迟、不完全恢复。
影响因子：
--
作者：
S. Hupp
通讯作者：
S. Hupp
第 1 章 – 铁在酶促脂质过氧化中的作用
DOI：
--
发表时间：
1982
期刊：
影响因子：
--
作者：
S. Aust;B. Svingen
通讯作者：
B. Svingen