Sensory nerves: A driver of the vicious cycle in bone metastasis?
Sensory nerves: A driver of the vicious cycle in bone metastasis?
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DOI：
10.1016/j.jbo.2021.100387
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发表时间：
2021-10
影响因子：
3.4
通讯作者：
Hata K
中科院分区：
文献类型：
--
作者：
Yoneda T;Hiasa M;Okui T;Hata K
骨受感觉神经的密集支配。感觉神经痛觉感受器TRPV1的兴奋诱导癌症相关的骨痛并促进骨癌的进展。感觉神经TRPV1是癌症进展和相关骨痛的治疗靶点。骨是肿瘤转移的首选靶器官之一。骨转移与各种并发症有关，其中骨痛是最常见和最虚弱的。癌症相关性骨痛（CABP）是由于感觉神经（SNs）的神经发生、重编程和轴突发生增加，与骨内肿瘤微环境对SNs的致敏和兴奋相协调而引起的。重要的是，CABP与死亡率增加有关，其精确的细胞和分子机制尚不清楚。骨被自主神经（交感神经和副交感神经）和SNs密集支配。近年来的研究表明，支配肿瘤微环境的神经与肿瘤建立了密切的联系，对肿瘤的进展和扩散产生各种刺激。在这篇综述中，我们目前对神经鞘神经支配骨在CABP病理生理中的作用的理解将被概述。然后，结合我们最近的发现，SNs不仅在CABP的诱导中起重要作用，而且在CABP的临床前模型中也起着骨转移的进展，讨论了SNs促进骨癌症进展的假设。这表明，SNs是骨微环境的一个关键组成部分，推动骨与癌症之间的恶性循环，促进骨转移。抑制骨神经支配性SNs的活性可能对骨转移的进展和CABP的诱导有潜在的治疗作用。
Bone is densely innervated by sensory nerves. Excitation of the sensory nerve nociceptor TRPV1 induces cancer-associated bone pain and promotes cancer progression in bone. Sensory nerve TRPV1 is a therapeutic target for cancer progression and associated bone pain. Bone is one of the preferential target organs of cancer metastasis. Bone metastasis is associated with various complications, of which bone pain is most common and debilitating. The cancer-associated bone pain (CABP) is induced as a consequence of increased neurogenesis, reprogramming and axonogenesis of sensory nerves (SNs) in harmony with sensitization and excitation of SNs in response to the tumor microenvironment created in bone. Importantly, CABP is associated with increased mortality, of which precise cellular and molecular mechanism remains poorly understood. Bone is densely innervated by autonomic nerves (ANs) (sympathetic and parasympathetic nerves) and SNs. Recent studies have shown that the nerves innervating the tumor microenvironment establish intimate communications with tumors, producing various stimuli for tumors to progress and disseminate. In this review, our current understanding of the role of SNs innervating bone in the pathophysiology of CABP will be overviewed. Then the hypothesis that SNs facilitate cancer progression in bone will be discussed in conjunction with our recent findings that SNs play an important role not only in the induction of CABP but also the progression of bone metastasis using a preclinical model of CABP. It is suggested that SNs are a critical component of the bone microenvironment that drives the vicious cycle between bone and cancer to progress bone metastasis. Suppression of the activity of bone-innervating SNs may have potential therapeutic effects on the progression of bone metastasis and induction of CABP.
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影响因子：
3.4
作者：
Coleman RE;Lipton A;Costa L;Cook RJ;Lee KA;Saad F;Brown JE;Terpos E;Major PP;Kohno N;Smith M;Body JJ
通讯作者：
Body JJ
影响因子：
7.4
作者：
Cheng Y;Sun F;D'Souza A;Dhakal B;Pisano M;Chhabra S;Stolley M;Hari P;Janz S
通讯作者：
Janz S
影响因子：
4.8
作者：
Andriessen AS;Donnelly CR;Ji RR
通讯作者：
Ji RR
影响因子：
51.1
作者：
Coleman, Robert;Finkelstein, Dianne M.;Chan, Arlene
通讯作者：
Chan, Arlene
影响因子：
3.3
作者：
Chartier SR;Mitchell SAT;Majuta LA;Mantyh PW
通讯作者：
Mantyh PW