The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur.
The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur.
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DOI：
10.1016/j.neuroscience.2018.01.047
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发表时间：
2018-09-01
期刊：
影响因子：
3.3
通讯作者：
Mantyh PW
中科院分区：
文献类型：
--
作者：
Chartier SR;Mitchell SAT;Majuta LA;Mantyh PW
尽管骨骼不断重塑并最终随着年龄的增长而衰退，但人们很少知道支配骨骼的感觉和交感神经纤维是否也会发生类似的变化。在这里，使用免疫组织化学和共聚焦显微镜检查支配年轻（产后 10 天）、成年（3 个月）和衰老（24 个月）C57Bl/6 小鼠股骨的感觉和交感神经纤维的变化。在所检查的所有三个年龄段中，骨膜是神经支配最密集的骨室。随着年龄的增长，随着骨膜形成层急剧变薄，感觉和交感神经纤维的总数明显下降。然而，即使在老化的股骨中，骨膜仍然存在密集的感觉和交感神经支配。在皮质骨中，感觉和交感神经纤维主要局限于血管化的哈弗氏管，虽然感觉纤维的密度没有显着下降，但与成人皮质骨相比，老龄化皮质骨中的交感神经纤维减少了 75%。相比之下，在骨髓中，感觉神经纤维和交感神经纤维的总体密度/单位面积似乎在整个生命周期中基本保持不变。感觉神经纤维的优先保留表明，即使骨骼本身随着年龄的增长而明显衰退，检测损伤和发出骨骼疼痛信号的伤害感受器仍然相对完整。
Although bone is continually being remodeled and ultimately declines with aging, little is known whether similar changes occur in the sensory and sympathetic nerve fibers that innervate bone. Here, immunohistochemistry and confocal microscopy were used to examine changes in the sensory and sympathetic nerve fibers that innervate the young (10 days post-partum), adult (3 months) and aging (24 months) C57Bl/6 mouse femur. In all three ages examined, the periosteum was the most densely innervated bone compartment. With aging, the total number of sensory and sympathetic nerve fibers clearly declines as the cambium layer of the periosteum dramatically thins. Yet even in the aging femur, there remains a dense sensory and sympathetic innervation of the periosteum. In cortical bone, sensory and sympathetic nerve fibers are largely confined to vascularized Haversian canals and while there is no significant decline in the density of sensory fibers, there was a 75% reduction in sympathetic nerve fibers in the aging vs. adult cortical bone. In contrast, in the bone marrow the overall density/unit area of both sensory and sympathetic nerve fibers appeared to remain largely unchanged across the lifespan. The preferential preservation of sensory nerve fibers suggests that even as bone itself undergoes a marked decline with age, the nociceptors that detect injury and signal skeletal pain remain relatively intact.
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影响因子：
19
作者：
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通讯作者：
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4.3
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