Toward digital staining using imaging mass spectrometry and random forests.
Toward digital staining using imaging mass spectrometry and random forests.
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DOI:
10.1021/pr900253y
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发表时间:
2009-07
影响因子:
4.4
通讯作者:
Hamprecht, Fred A.
中科院分区:
文献类型:
--
作者:
Hanselmann, Michael;Kothe, Ullrich;Kirchner, Marc;Renard, Bernhard Y.;Amstalden, Erika R.;Glunde, Kristine;Heeren, Ron M. A.;Hamprecht, Fred A.
关键词:
We show on Imaging Mass Spectrometry (IMS) data that the Random Forest classifier can be used for automated tissue classification and that it results in predictions with high sensitivities and positive predictive values, even when inter-sample variability is present in the data. We further demonstrate how Markov Random Fields and vector-valued median filtering can be applied to reduce noise effects to further improve the classification results in a post-hoc smoothing step. Our study gives clear evidence that digital staining by means of IMS constitutes a promising complement to chemical staining techniques.
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通讯作者:
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DOI:
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发表时间:
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