The influence of hepatic function on prostate cancer outcomes after radical prostatectomy.
The influence of hepatic function on prostate cancer outcomes after radical prostatectomy.
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DOI：
10.1038/pcan.2010.3
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发表时间：
2010-06
影响因子：
4.8
通讯作者：
Terris, M. K.
中科院分区：
文献类型：
--
作者：
Banez, L. L.;Loftis, R. M.;Freedland, S. J.;Presti, J. C., Jr.;Aronson, W. J.;Amling, C. L.;Kane, C. J.;Terris, M. K.
前列腺的生长依赖于循环雄激素，而循环雄激素可受肝功能的影响。肝病已被认为影响前列腺癌（CaP）的发病率。然而，尚未研究肝功能对CaP结局的影响。在1988年至2008年期间，共有1，181名患者在四家退伍军人事务部医院接受了根治性肝切除术（RP），这些医院包括共享平等访问区域癌症医院（Shared Equal Access Regional Cancer Hospital，简称ERC）数据库，并有可用的肝功能检查（LFT）数据。使用logistic和考克斯回归分析确定LFT与不良病理特征和生化复发的独立相关性。血清谷草转氨酶（SGOT）和血清谷丙转氨酶（SGPT）水平升高的患者分别为8.2%和4.4%。在控制CaP特征后，逻辑回归显示SGOT水平与病理性Gleason总和≥7（4+3）癌症之间存在显著相关性（比值比=2.12; 95%置信区间=1.11-4.05; p=0.02）。轻度肝功能障碍与不良CaP分级显著相关，但与接受R的男性队列中的其他不良病理特征或生化复发无显著相关性。中度至重度肝病对非手术治疗的CaP患者疾病结局的影响仍有待研究。
Prostate growth is dependent on circulating androgens which can be influenced by hepatic function. Liver disease has been suggested to influence prostate cancer (CaP) incidence. However, the effect of hepatic function on CaP outcomes has not been investigated. A total of 1,181 patients who underwent radical prostatectomy (RP) between 1988 and 2008 at four Veterans Affairs hospitals that comprise the Shared Equal Access Regional Cancer Hospital (SEARCH) database and had available liver function test (LFT) data were included in the study. Independent associations of LFTs with unfavorable pathological features and biochemical recurrence were determined using logistic and Cox regression analyses. Serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels were elevated in 8.2% and 4.4% of patients, respectively. After controlling for CaP features, logistic regression revealed a significant association between SGOT levels and pathological Gleason sum ≥7(4+3) cancer (odds ratio=2.12; 95% confidence interval=1.11-4.05; p=0.02). Mild hepatic dysfunction was significantly associated with adverse CaP grade but was not significantly associated with other adverse pathological features or biochemical recurrence in a cohort of men undergoing R. The effect of moderate to severe liver disease on disease outcomes in CaP patients managed non-surgically remains to be investigated.
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DOI：
10.1111/j.1365-2362.1978.tb00841.x
发表时间：
1978-01-01
影响因子：
5.5
作者：
LINDHOLM, J;FABRICIUSBJERRE, N;CHRISTENSEN, T
通讯作者：
CHRISTENSEN, T
影响因子：
158.5
作者：
Thompson, IM;Goodman, PJ;Coltman, CA
通讯作者：
Coltman, CA
影响因子：
3.8
作者：
Severi, G;Morris, HA;Giles, GG
通讯作者：
Giles, GG
DOI：
10.1093/jnci/88.16.1118
发表时间：
1996-08-21
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Gann, PH;Hennekens, CH;Stampfer, MJ
通讯作者：
Stampfer, MJ
影响因子：
10.3
作者：
Lucia, M. Scott;Epstein, Jonathan I.;Thompson, Ian M.
通讯作者：
Thompson, Ian M.