Effects of high-fat diet exposure on learning & memory.

Effects of high-fat diet exposure on learning & memory.
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DOI:
10.1016/j.physbeh.2015.06.008
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发表时间:
2015-12-01
影响因子:
2.9
通讯作者:
Tamashiro KL
Tamashiro KL
中科院分区:
医学3区
文献类型:
--
作者:
Cordner ZA;Tamashiro KL

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人们早已认识到高脂肪或“西方”饮食与肥胖、糖尿病和心血管疾病等代谢紊乱之间的关联,现在大量证据表明,高脂肪饮食也会对大脑、行为和认知产生深远影响。在这里,我们将回顾最常用于评估啮齿动物模型学习和记忆的技术,并讨论评估高脂肪饮食对认知影响的研究结果。然后,该综述将考虑大脑中潜在的潜在机制,并通过回顾新兴文献得出结论,这些文献表明母亲食用高脂肪饮食可能会对后代的学习和记忆产生影响。
The associations between consumption of a high-fat or ‘Western’ diet and metabolic disorders such as obesity, diabetes, and cardiovascular disease have long been recognized and a great deal of evidence now suggests that diets high in fat can also have a profound impact on the brain, behavior, and cognition. Here, we will review the techniques most often used to assess learning and memory in rodent models and discuss findings from studies assessing the cognitive effects of high-fat diet consumption. The review will then consider potential underlying mechanisms in the brain and conclude by reviewing emerging literature suggesting that maternal consumption of a high-fat diet may have effects on the learning and memory of offspring.
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期刊: NEUROSCIENCE
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