Inter-relationships among diet, obesity and hippocampal-dependent cognitive function.
Inter-relationships among diet, obesity and hippocampal-dependent cognitive function.
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DOI：
10.1016/j.neuroscience.2013.08.044
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发表时间：
2013-12-03
期刊：
影响因子：
3.3
通讯作者：
Zheng, W.
中科院分区：
文献类型：
--
作者：
Davidson, T. L.;Hargrave, S. L.;Swithers, S. E.;Sample, C. H.;Fu, X.;Kinzig, K. P.;Zheng, W.
西方饮食（WD），这是高饱和脂肪和糖的摄入量，与海马依赖性学习和记忆过程的缺陷，以及与海马病理学的标志物。在本研究中，大鼠被训练为渐进的依赖于大脑的连续特征阴性（FN）和不依赖于大脑的简单辨别问题。然后在自由进食食物7天后和维持WD、高饱和脂肪和低糖及其他碳水化合物的生酮（KETO）饮食或继续维持食物（CHOW）10、24、40、60和90天后评估性能。重复和扩展先前的发现，与CHOW对照组和维持WD时未变得肥胖的饮食抵抗（DR）大鼠相比，喂食WD的饮食诱导肥胖（DIO）大鼠显示受损的FN性能、增加的BBB渗透性和增加的空腹血糖水平。对于喂食KETO饲料的大鼠，FN性能和BBB完整性与循环酮体水平的相关性比与肥胖表型（DR或DIO）的相关性更密切，更高水平的酮体似乎提供了保护作用。证据还表明，FN赤字之前和预测体重增加和肥胖。这项研究（a）进一步证实了先前的研究结果，即WD诱导的大脑皮层依赖性特征负性辨别缺陷，（B）表明酮可能对饮食诱导的认知障碍具有保护作用，（c）提供了饮食诱导的认知障碍先于体重增加和肥胖的证据。
Intake of a Western diet (WD), which is high in saturated fat and sugar, is associated with deficits in hippocampal-dependent learning and memory processes as well as with markers of hippocampal pathology. In the present study, rats were trained to asymptote on hippocampal-dependent serial feature negative (FN) and hippocampal-independent simple discrimination problems. Performance was then assessed following 7 days on ad libitum chow and after 10, 24, 40, 60, and 90 days of maintenance on WD, on ketogenic (KETO) diet which is high in saturated fat and low in sugar and other carbohydrates, or continued maintenance on chow (CHOW). Confirming and extending previous findings, diet-induced obese (DIO) rats fed WD showed impaired FN performance, increased BBB permeability, and increased fasting blood glucose levels compared to CHOW controls and to diet resistant (DR) rats that did not become obese when maintained on WD. For rats fed the KETO diet, FN performance and BBB integrity was more closely associated with level of circulating ketone bodies than with obesity phenotype (DR or DIO) with higher levels of ketones appearing to provide a protective effect. The evidence also indicated that FN deficits preceded and predicted increased body weight and adiposity. This research (a) further substantiates previous findings of WD-induced deficits in hippocampal-dependent feature negative discriminations, (b) suggests that ketones may be protective against diet-induced cognitive impairment, and (c) provides evidence that diet-induced cognitive impairment precedes weight gain and obesity.
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影响因子：
2.9
作者：
Davidson TL;Monnot A;Neal AU;Martin AA;Horton JJ;Zheng W
通讯作者：
Zheng W
影响因子：
2.2
作者：
Hallböök T;Ji S;Maudsley S;Martin B
通讯作者：
Martin B
影响因子：
2.9
作者：
Davidson, TL;Kanoski, SE;Jarrard, LE
通讯作者：
Jarrard, LE
影响因子：
4
作者：
Didic, Mira;Barbeau, Emmanuel J.;Ceccaldi, Mathieu
通讯作者：
Ceccaldi, Mathieu
DOI：
10.1038/oby.2005.205
发表时间：
2005-10-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Kinzig, KP;Scott, KA;Moran, TH
通讯作者：
Moran, TH