The luteinizing hormone receptor: insights into structure-function relationships and hormone-receptor-mediated changes in gene expression in ovarian cancer cells.
The luteinizing hormone receptor: insights into structure-function relationships and hormone-receptor-mediated changes in gene expression in ovarian cancer cells.
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DOI：
10.1016/j.mce.2010.04.025
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发表时间：
2010-11-25
影响因子：
4.1
通讯作者：
Fanelli, Francesca
中科院分区：
文献类型：
--
作者：
Puett, David;Angelova, Krassimira;da Costa, Marcelo Rocha;Warrenfeltz, Susanne W.;Fanelli, Francesca
关键词：
黄体生成素受体(LHR)是三种糖蛋白激素受体之一，在性腺类固醇激素生成、卵母细胞成熟排卵和男性性别分化等生殖过程中起重要作用。此外，它还被认为与某些肿瘤有关，尤其是卵巢癌。作为G蛋白偶联受体家族的一员，LHR含有一个相对较大的胞外结构域，负责高亲和力激素结合；跨膜激活然后导致G蛋白偶联和随后的第二信使产生。本文就LHR的结构和结构-功能关系以及激素对表达LHR的卵巢癌细胞基因表达的影响等方面的最新研究进展作一综述。还提出了随着该领域的发展需要填补的关键空白，包括确定非活性和活性受体的三维结构，阐明激素与细胞外结构域结合触发Gs激活的机制，澄清LHR在非性腺组织中的假定作用，以及激活的受体在卵巢癌发生发展中的作用(如果有的话)。
The luteinizing hormone receptor (LHR), one of the three glycoprotein hormone receptors, is necessary for critical reproductive processes, including gonadal steroidogenesis, oocyte maturation and ovulation, and male sex differentiation. Moreover, it has been postulated to contribute to certain neoplasms, particularly ovarian cancer. A member of the G protein-coupled receptor family, LHR contains a relatively large extracellular domain responsible for high affinity hormone binding; transmembrane activation then leads to G protein coupling and subsequent second messenger production. This review deals with recent advances in our understanding of LHR structure and structure-function relationships, as well as hormone-mediated changes in gene expression in ovarian cancer cells expressing LHR. Suggestions are also made for critical gaps that need to be filled as the field advances, including determination of the three-dimensional structure of inactive and active receptor, elucidation of the mechanism by which hormone binding to the extracellular domain triggers the activation of Gs, clarification of the putative roles of LHR in non-gonadal tissues, and the role, if any, of activated receptor in the development or progression of ovarian cancer.
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影响因子：
5.6
作者：
Gabb, HA;Jackson, RM;Sternberg, MJE
通讯作者：
Sternberg, MJE
影响因子：
4.8
作者：
Angelova, K;Fanelli, F;Puett, D
通讯作者：
Puett, D
影响因子：
4.1
作者：
Bogerd, J.
通讯作者：
Bogerd, J.
DOI：
10.1046/j.1432-1327.1999.00188.x
发表时间：
1999-03-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Erbel, PJA;Karimi-Nejad, Y;Vliegenthart, JFG
通讯作者：
Vliegenthart, JFG
影响因子：
--
作者：
Fralish, GB;Dattilo, B;Puett, D
通讯作者：
Puett, D