Tumors Are Evolutionary Island-Like Ecosystems.
Tumors Are Evolutionary Island-Like Ecosystems.
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DOI：
10.1093/gbe/evab276
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发表时间：
2021-12-01
影响因子：
3.3
通讯作者：
Kumar S
中科院分区：
文献类型：
--
作者：
Chroni A;Kumar S
生态和进化特征的整合已经开始了解肿瘤异质性、微环境和转移潜力之间的相互作用。开发一个理论框架对于破译患者肿瘤巨大的空间和纵向遗传变异模式是内在的。在这里，我们认为肿瘤可以被认为是进化的岛状生态系统，即经历进化和时空动态过程的孤立系统，这些过程塑造了肿瘤微环境并驱动癌细胞的迁移。我们研究了岛屿系统的属性和形成孤岛的原因，如物理距离和连通性。这些特性通过导致器官和组织在空间和时间上隔离的过程来调节癌细胞的迁移率，这些器官和组织为新的定居提供癌细胞。我们讨论假设，预测，和限制的肿瘤作为岛屿类比。我们提出了不同癌症类型中肿瘤岛性的新证据，并讨论了它们与孤岛模型的相关性。我们认为，将肿瘤的岛性引入概念模型和数学模型有望阐明肿瘤的进化、肿瘤的异质性和细胞的转移潜能。
Integration of ecological and evolutionary features has begun to understand the interplay of tumor heterogeneity, microenvironment, and metastatic potential. Developing a theoretical framework is intrinsic to deciphering tumors’ tremendous spatial and longitudinal genetic variation patterns in patients. Here, we propose that tumors can be considered evolutionary island-like ecosystems, that is, isolated systems that undergo evolutionary and spatiotemporal dynamic processes that shape tumor microenvironments and drive the migration of cancer cells. We examine attributes of insular systems and causes of insularity, such as physical distance and connectivity. These properties modulate migration rates of cancer cells through processes causing spatial and temporal isolation of the organs and tissues functioning as a supply of cancer cells for new colonizations. We discuss hypotheses, predictions, and limitations of tumors as islands analogy. We present emerging evidence of tumor insularity in different cancer types and discuss their relevance to the islands model. We suggest that the engagement of tumor insularity into conceptual and mathematical models holds promise to illuminate cancer evolution, tumor heterogeneity, and metastatic potential of cells.
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DOI：
10.1158/1541-7786.mcr-16-0436
发表时间：
2017-04
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
de Groot AE;Roy S;Brown JS;Pienta KJ;Amend SR
通讯作者：
Amend SR
影响因子：
29.4
作者：
Ding, Xiaofan;He, Mian;Wong, Nathalie
通讯作者：
Wong, Nathalie
影响因子：
30.8
作者：
Chan-Seng-Yue, Michelle;Kim, Jaeseung C.;Notta, Faiyaz
通讯作者：
Notta, Faiyaz
影响因子：
3.2
作者：
Galizia, Gennaro;Gemei, Marica;Lieto, Eva
通讯作者：
Lieto, Eva
影响因子：
5.2
作者：
Chroni, Antonia;Vu, Tracy;Kumar, Sudhir
通讯作者：
Kumar, Sudhir