Resistance is futile: targeting multidrug-resistant bacteria with de novo Cys-rich cyclic polypeptides.
Resistance is futile: targeting multidrug-resistant bacteria with de novo Cys-rich cyclic polypeptides.
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DOI：
10.1039/d3cb00015j
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发表时间：
2023-10-04
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
寻找新的抗微生物药物来对抗微生物病原体正在加强响应快速耐药性发展对目前的抗生素治疗。利用富含二硫化物的首尾环化多肽作为分子框架设计新型肽类抗生素正日益受到科学界和制药行业的关注。大环肽的使用，进一步受到几个二硫键的存在的限制，使得这些肽框架在热、生物和化学降解方面表现出比它们的线性类似物更好的活性。许多这些新型肽支架已被证明对那些不涉及二硫键的残基序列变异性具有很高的耐受性，能够穿过生物膜，并有效地靶向复杂的生物分子相互作用。因此，这些独特的特性使这些支架的使用成为许多生物技术应用的理想选择，包括设计新型肽抗生素。本文综述了几种富含二硫化物的环状多肽的新进展，包括环肽、θ-防御素和向日葵胰蛋白酶抑制剂肽等，用于开发抗多药耐药细菌的新型抗菌肽。寻找新的抗微生物药物来对抗微生物病原体正在加强响应快速耐药性发展对目前的抗生素治疗。
The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response to rapid drug resistance development to current antibiotic therapeutics. The use of disulfide-rich head-to-tail cyclized polypeptides as molecular frameworks for designing a new type of peptide antibiotics is gaining increasing attention among the scientific community and the pharmaceutical industry. The use of macrocyclic peptides, further constrained by the presence of several disulfide bonds, makes these peptide frameworks remarkably more stable to thermal, biological, and chemical degradation showing better activities when compared to their linear analogs. Many of these novel peptide scaffolds have been shown to have a high tolerance to sequence variability in those residues not involved in disulfide bonds, able to cross biological membranes, and efficiently target complex biomolecular interactions. Hence, these unique properties make the use of these scaffolds ideal for many biotechnological applications, including the design of novel peptide antibiotics. This article provides an overview of the new developments in the use of several disulfide-rich cyclic polypeptides, including cyclotides, θ-defensins, and sunflower trypsin inhibitor peptides, among others, in the development of novel antimicrobial peptides against multidrug-resistant bacteria. The search for novel antimicrobial agents to combat microbial pathogens is intensifying in response to rapid drug resistance development to current antibiotic therapeutics.
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影响因子：
--
作者：
Gould A;Li Y;Majumder S;Garcia AE;Carlsson P;Shekhtman A;Camarero JA
通讯作者：
Camarero JA
影响因子：
2.9
作者：
Garcia, Angie E.;Tai, Kenneth P.;Puttamadappa, Shadakshara S.;Shekhtman, Alexander;Ouellette, Andre J.;Camarero, Julio A.
通讯作者：
Camarero, Julio A.
影响因子：
7.3
作者：
Li Y;Gould A;Aboye T;Bi T;Breindel L;Shekhtman A;Camarero JA
通讯作者：
Camarero JA
影响因子：
4.5
作者：
Koehbach J;Gani J;Hilpert K;Craik DJ
通讯作者：
Craik DJ