Detecting and Monitoring Hydrogels with Medical Imaging.
Detecting and Monitoring Hydrogels with Medical Imaging.
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DOI：
10.1021/acsbiomaterials.0c01547
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发表时间：
2021-09-13
影响因子：
5.8
通讯作者：
Cormode DP
中科院分区：
文献类型：
--
作者：
Dong YC;Bouché M;Uman S;Burdick JA;Cormode DP
水凝胶，水溶胀的聚合物网络，由于其潜在的可调流变特性、可注射到组织中以及治疗剂的封装和释放，正被应用于许多生物医学应用，例如药物递送和组织工程。尽管它们有希望，但在体内评估它们的性质是具有挑战性的，并且通常缺乏关键信息，例如水凝胶在给药部位的保留和原位降解动力学。为了解决这个问题，近年来已经开发了用各种成像技术在体内评估和跟踪水凝胶的技术，包括用造影剂产生材料官能化的水凝胶，其可以用诸如X射线计算机断层扫描（CT）、磁共振成像（MRI）、光学成像和核成像系统的方法成像。在这篇综述中，我们将讨论新兴的方法来标记水凝胶成像，审查这些成像技术的优点和局限性，并突出显示这些技术已在生物医学应用中实施的例子。
Hydrogels, water-swollen polymer networks, are being applied to numerous biomedical applications, such as drug delivery and tissue engineering, due to their potential tunable rheologic properties, injectability into tissues, and encapsulation and release of therapeutics. Despite their promise, it is challenging to assess their properties in vivo and crucial information such as hydrogel retention at the site of administration and in situ degradation kinetics are often lacking. To address this, technologies to evaluate and track hydrogels in vivo with various imaging techniques have been developed in recent years, including hydrogels functionalized with contrast generating material that can be imaged with methods such as X-ray computed tomography (CT), magnetic resonance imaging (MRI), optical imaging, and nuclear imaging systems. In this review, we will discuss emerging approaches to label hydrogels for imaging, review the advantages and limitations of these imaging techniques, and highlight examples where such techniques have been implemented in biomedical applications.
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DOI：
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发表时间：
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期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
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