Network pharmacology-based analysis of Resinacein S against non-alcoholic fatty liver disease by modulating lipid metabolism.
Network pharmacology-based analysis of Resinacein S against non-alcoholic fatty liver disease by modulating lipid metabolism.
复制标题
基于网络药理学的分析，树脂蛋白S通过调节脂质代谢对抗非酒精性脂肪性肝病。
DOI：
10.3389/fnut.2023.1076569
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发表时间：
2023
影响因子：
5
通讯作者：
Cheng, Shu-Qun
中科院分区：
文献类型：
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作者：
Mao, Fei-Fei;Gao, Shan-Shan;Huang, Yan-Jie;Zhou, Nian;Feng, Jin-Kai;Liu, Zong-Han;Zhang, Yu-Qing;Yuan, Lu-Yun;Wei, Gang;Cheng, Shu-Qun
Ganoderma lucidum is reportedly the best source of traditional natural bioactive constituents. Ganoderma triterpenoids (GTs) have been verified as an alternative adjuvant for treating leukemia, cancer, hepatitis and diabetes. One of the major triterpenoids, Resinacein S, has been found to regulate lipid metabolism and mitochondrial biogenesis. Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that has become a major public health problem. Given the regulatory effects on lipid metabolism of Resinacein S, we sought to explore potential protective effects against NAFLD. Resinacein S was extracted and isolated from G. lucidum. And mice were fed with high fat diet with or without Resinacein S to detect hepatic steatosis. According to Network Pharmacology and RNA-seq, we analyzed the hub genes of Resinacein S against NAFLD disease. Our results can be summarized as follows: (1) The structure of Resinacein S was elucidated using NMR and MS methods. (2) Resinacein S treatment could significantly attenuate high-fat diet (HFD)-induced hepatic steatosis and hepatic lipid accumulation in mouse. (3) GO terms, KEGG pathways and the PPI network of Resinacein S induced Differentially Expressed Genes (DEGs) demonstrated the key target genes of Resinacein S against NAFLD. (4) The hub proteins in PPI network analysis could be used for NAFLD diagnosis and treatment as drug targets. Resinacein S can significantly change the lipid metabolism in liver cells and yield a protective effect against steatosis and liver injury. Intersected proteins between NAFLD related genes and Resinacein S-induced DEGs, especially the hub protein in PPI network analysis, can be used to characterize targets of Resinacein S against NAFLD.
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影响因子：
11.4
作者：
Li L;Wang H;Yao Y;Cao J;Jiang Z;Yan W;Chu X;Li Q;Lu M;Ma H
通讯作者：
Ma H
影响因子：
4.5
作者：
Hu, Qichao;Wei, Shizhang;Ma, Xiao
通讯作者：
Ma, Xiao
影响因子：
5.1
作者：
Manne, Vignan;Handa, Priya;Kowdley, Kris V.
通讯作者：
Kowdley, Kris V.
影响因子：
13.5
作者：
Charlton, Michael;Angulo, Paul;Lindor, Keith
通讯作者：
Lindor, Keith
影响因子：
3.8
作者：
通讯作者：
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