Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.
Structure and inhibition of EV-D68, a virus that causes respiratory illness in children.
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DOI：
10.1126/science.1261962
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发表时间：
2015-01-02
期刊：
影响因子：
--
通讯作者：
Rossmann MG
中科院分区：
文献类型：
--
作者：
Liu Y;Sheng J;Fokine A;Meng G;Shin WH;Long F;Kuhn RJ;Kihara D;Rossmann MG
肠道病毒D68(EV-D68)是美国最近暴发的儿童呼吸道疾病的病原体，是短小病毒科的成员。我们报道了EV-D68及其与Peconaril的络合物的晶体结构，pleconaril是一种衣壳结合化合物，已被开发用于抗鼻病毒药物。病毒蛋白1的疏水药物结合口袋含有与约10个碳原子的脂肪酸一致的密度。这种密度可以被普罗卡尼利取代。我们还表明，普利康利对EV-D68的半数最大有效浓度(EC50)为430 nM，因此可能是缓解EV-D68暴发的候选药物。
Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks in the USA of respiratory illness in children. We report here the crystal structures of EV-D68 and its complex with pleconaril, a capsid binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. We also showed that pleconaril inhibits EV-D68 at a half maximal effective concentration (EC50) of 430 nM and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks.
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影响因子：
56.9
作者：
SMITH, TJ;KREMER, MJ;OTTO, MJ
通讯作者：
OTTO, MJ
影响因子：
5.4
作者：
Ledford, RM;Patel, NR;Pevear, DC
通讯作者：
Pevear, DC
影响因子：
5.4
作者：
SHERRY, B;MOSSER, AG;RUECKERT, RR
通讯作者：
RUECKERT, RR
DOI：
10.1073/pnas.90.2.507
发表时间：
1993-01-15
影响因子：
11.1
作者：
OLSON, NH;KOLATKAR, PR;ROSSMANN, MG
通讯作者：
ROSSMANN, MG
DOI：
10.1107/s0907444998003254
发表时间：
1998-09-01
期刊：
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
影响因子：
--
作者：
Brunger, AT;Adams, PD;Warren, GL
通讯作者：
Warren, GL