Testing of a Noninvasive Probe for Measurement of Blood Perfusion
Testing of a Noninvasive Probe for Measurement of Blood Perfusion
复制标题
用于测量血液灌注的无创探针的测试
DOI：
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复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
T. Diller
中科院分区：
文献类型：
--
作者：
P. S. Robinson;E. Scott;T. Diller
参数估计技术已被用于开发一种方法，使用新的热表面探头无创测量血液灌注。该探头的核心由一个小型、轻质的热通量传感器组成，该传感器与组织接触放置，并在探头由空气射流冷却时提供热通量和表面温度的时间分辨信号。参数估计技术的开发，将热通量和温度数据与计算数据从一个biopsique模型的组织和探头。该技术同时估计探头和组织之间的血液灌注和热接触电阻。通过非生物多孔介质的受控流动实验验证了这一概念。温水通过细孔海绵循环，以提供用于通过生物组织的血液灌注的体模模型。参数估计技术被施加到在一个范围内的流量的测量。热通量和温度测量和由此产生的灌注估计相关性以及实验施加的灌注率。这项研究有助于建立使用这种方法来开发一种实用的，非侵入性的探头，临床测量血液灌注的有效性。
Parameter estimation techniques have been utilized in the development of a methodology to noninvasively measure blood perfusion using a new thermal surface probe. The core of this probe is comprised of a small, lightweight heat flux sensor that is placed in contact with tissue and provides time-resolved signals of heat flux and surface temperature while the probe is cooled by air jets. Parameter estimation techniques were developed that incorporate heat flux and temperature data with calculated data from a biothermal model of the tissue and probe. The technique simultaneously estimates blood perfusion and thermal contact resistance between the probe and tissue. Validation of this concept was carried out by experimentation with controlled flow through nonbiological porous media. Warm water was circulated through a fine pore sponge to provide a phantom model for blood perfusion through biological tissue. The parameter estimation technique was applied to measurements taken over a range of flow rates. Heat flux and temperature measurements and the resulting perfusion estimates correlated well with the experimentally imposed perfusion rate. This research helps establish the validity of using this method to develop a practical, noninvasive probe to clinically measure blood perfusion.
运动期间的局部灌注和代谢需求：一种无创 MRI 评估方法。
DOI：
10.1152/jappl.2001.91.4.1845
发表时间：
2001
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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作者：
Richardson,RS;Haseler,LJ;Nygren,AT;Bluml,S;Frank,LR
通讯作者：
Frank,LR
DOI：
10.1115/1.2792273
发表时间：
1995
期刊：
Journal of biomechanical engineering
影响因子：
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作者：
Wei,D;Saidel,GM;Jones,SC
通讯作者：
Jones,SC
DOI：
10.1115/1.3138689
发表时间：
1987-11-01
影响因子：
1.7
作者：
PATEL, PA;VALVANO, JW;DENHAM, CR
通讯作者：
DENHAM, CR