The physiology of foamy phagocytes in multiple sclerosis.
The physiology of foamy phagocytes in multiple sclerosis.
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DOI：
10.1186/s40478-018-0628-8
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发表时间：
2018-11-19
影响因子：
7.1
通讯作者：
Bogie JFJ
中科院分区：
文献类型：
--
作者：
Grajchen E;Hendriks JJA;Bogie JFJ
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions mainly consist of macrophages and microglia containing abundant intracellular myelin remnants. Initial studies showed that these foamy phagocytes primarily promote MS disease progression by internalizing myelin debris, presenting brain-derived autoantigens, and adopting an inflammatory phenotype. However, more recent studies indicate that phagocytes can also adopt a beneficial phenotype upon myelin internalization. In this review, we summarize and discuss the current knowledge on the spatiotemporal physiology of foamy phagocytes in MS lesions, and elaborate on extrinsic and intrinsic factors regulating their behavior. In addition, we discuss and link the physiology of myelin-containing phagocytes to that of foamy macrophages in other disorders such atherosclerosis.
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影响因子：
4.6
作者：
Bogie, Jeroen F. J.;Mailleux, Jo;Hendriks, Jerome J. A.
通讯作者：
Hendriks, Jerome J. A.
影响因子：
3.6
作者：
Besler, HT;Çomoglu, S
通讯作者：
Çomoglu, S
影响因子：
11.2
作者：
Breij, Esther C. W.;Brink, Bianca P.;Boe, Lars
通讯作者：
Boe, Lars
影响因子：
6
作者：
Boyle, Joseph J.;Harrington, Heather A.;Haskard, Dorian O.
通讯作者：
Haskard, Dorian O.
影响因子：
9.3
作者：
Burm SM;Peferoen LA;Zuiderwijk-Sick EA;Haanstra KG;'t Hart BA;van der Valk P;Amor S;Bauer J;Bajramovic JJ
通讯作者：
Bajramovic JJ