Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma
Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma
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Mus81 的下调作为结直肠癌患者的新型预后生物标志物
DOI：
10.1111/j.1349-7006.2010.01790.x
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发表时间：
2011-02
期刊：
影响因子：
5.7
通讯作者：
Hiroshi Nemoto
中科院分区：
文献类型：
--
作者：
Kenji Hibi;Atsushi Shirahata;Kazuma Sakuraba;Yohei Kitamura;Tetsuhiro Goto;Mitsuo Saito;Kazuyoshi Ishibashi;Gaku Kigawa;Hiroshi Nemoto
Mus 81基因编码参与DNA修复和肿瘤抑制的关键核酸内切酶。我们的前期研究表明，肝细胞癌中Mus 81的表达降低，其与肝细胞癌的潜在的和预后的关系。然而，Mus 81在结直肠癌中的作用目前尚不清楚。因此，我们进行了本研究，以探讨Mus 81的表达和大肠癌的进展之间的相关性。应用定量真实的时间聚合酶链反应（RT-PCR）检测92例结直肠癌组织及癌旁正常组织中Mus 81的表达。结果显示，大肠癌组织中Mus 81的表达明显低于正常大肠组织（P <0.001），其中60.9%（56/92）的大肠癌组织中Mus 81表达下调（下调50%以上）。 此外，Mus 81表达下调与结直肠癌肝转移（P = 0.019）和高TNM分期（P = 0.025）显著相关。 另外，10例肝转移癌组织中Mus 81表达较相应的原发癌组织明显降低（P = 0.016）。 更重要的是，具有明显Mus 81下调的结直肠癌患者的总体生存率显著低于Mus 81下调很少的结直肠癌患者（P = 0.0374）。 此外，多变量考克斯回归分析确定Mus 81下调为结直肠癌的独立预后因素（风险比，1.678; P = 0.040）。 结论：Mus 81的低表达与结直肠癌的肝转移和预后密切相关，提示Mus 81可作为结直肠癌的一个新的预后指标。（Cancer Sci 2011; 102：472-477）
The Mus81 gene encodes a critical endonuclease involved in DNA repair and tumor suppression. Our previous study has shown reduced expression of Mus81 in hepatocellular carcinoma and its association with the metastastic potential and prognosis of hepatocellular carcinoma. However, the role of Mus81 in colorectal carcinoma is currently unknown. We therefore carried out the present study to explore the correlation between Mus81 expression and the progression of colorectal carcinoma. Mus81 expression in 92 cases of colorectal carcinoma and matched normal tissues was determined by quantitative real‐time polymerase chain reaction. Our results showed that Mus81 expression in colorectal carcinoma tissues was significantly reduced compared with the corresponding normal tissues (P < 0.001) and the downregulation of Mus81 (decreased by more than 50%) was found in 60.9% (56/92) of colorectal carcinoma. Moreover, Mus81 downregulation correlated significantly to hepatic metastasis (P = 0.019) and a high TNM stage (P = 0.025) of colorectal carcinoma. In addition, the decrease of Mus81 was also detected in 10 cases of hepatic metastasis tissues compared with the corresponding primary colorectal carcinoma tissues (P = 0.016). More importantly, colorectal carcinoma patients with apparent Mus81 downregulation have shown significantly poorer overall survival than those with little Mus81 downregulation (P = 0.0374). Also, multivariable Cox regression analysis identified Mus81 downregulation as an independent prognostic factor for colorectal carcinoma (hazard ratio, 1.678; P = 0.040). In conclusion, the reduced expression of Mus81 is closely related to hepatic metastasis and poor prognosis of colorectal carcinoma, indicating Mus81 as a novel prognostic marker for colorectal carcinoma. (Cancer Sci 2011; 102: 472–477)
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影响因子：
56.9
作者：
NISHISHO, I;NAKAMURA, Y;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B
影响因子：
4
作者：
T. Pwint;R. Midgley;D. Kerr
通讯作者：
T. Pwint;R. Midgley;D. Kerr
影响因子：
6.2
作者：
Fan Wu;Sile Liu;Yi-ming Tao;Di-peng Ou;F. Fang;Lian-yue Yang
通讯作者：
Fan Wu;Sile Liu;Yi-ming Tao;Di-peng Ou;F. Fang;Lian-yue Yang
影响因子：
4.8
作者：
Tay, Ye Dee;Wu, Leonard
通讯作者：
Wu, Leonard
影响因子：
5.7
作者：
Sakakibara, T;Hibi, K;Nakao, A
通讯作者：
Nakao, A