Obligatory role of luteinizing hormone (LH) in the initiation of preovulatory follicular growth in the pregnant rat: specific effects of human chorionic gonadotropin and follicle-stimulating of hormone on LH receptors and steroidogenesis in theca, granulosa, and luteal cells.-猫眼课题宝

黄体生成素 (LH) 在妊娠大鼠排卵前卵泡生长启动中的必然作用：人绒毛膜促性腺激素和卵泡刺激激素对 LH 受体以及卵泡膜、颗粒和黄体细胞中类固醇生成的特定作用。

DOI：

发表时间：

1981

期刊：

Endocrinology

影响因子：

4.8

通讯作者：

中科院分区：

医学2区

文献类型：

作者：

K. Bogovich;J. Richards;L. Reichert

大鼠妊娠末期排卵前卵泡发育伴随的血清激素浓度变化表明，卵泡成熟是由血清LH的轻微增加和/或血清孕酮的减少而不是血清FSH的增加刺激的。为了检测小窦非排卵卵泡对LH样活性在血清孕酮升高、hCG（0.25 - 3.0 IU）或对照组存在下的轻微增加的反应能力，在妊娠第14天和第15天对大鼠每日两次给予人FSH（hFSH）（0.88 - 4.4 IU）。hCG刺激卵泡生长，增加颗粒细胞和卵泡膜细胞LH受体含量，并以时间相关和剂量依赖的方式增加卵泡雌二醇的积累。用1.5 IU hCG（3.5 pmol）每日两次处理2天的动物的卵泡在第16天与第23天分离的发情前期卵泡功能相同，并且推注10 IU hCG能够诱导这些hCG引发的卵泡排卵。

The changes in serum hormone concentrations accompanying preovulatory follicular development at the end of pregnancy in the rat suggest that follicular maturation is stimulated by subtle increases in serum LH and/or by a decrease in serum progesterone but not by increases in serum FSH. To test the ability of small antral nonovulatory follicles to respond to subtle increases in LH-like activity in the presence of elevated serum progesterone, hCG (0.25 to 3.0 IU), or the control, human FSH (hFSH) (0.88 to 4.4 IU) was administered twice daily to rats on days 14 and 15 of pregnancy. hCG stimulated follicular growth, increased granulosa cell and theca cell LH receptor content, and enhanced follicular estradiol accumulation in a time-related and dose-dependent manner. Follicles from animals treated twice daily for 2 days with 1.5 IU hCG (3.5 pmol) were by day 16 functionally identical to proestrous follicles isolated on day 23, and a bolus injection of 10 IU hCG was able to induce ovulation in these hCG-primed ...

Differential processing of subunits of human chorionic gonadotropin by granulosa cells in vivo.